Pivalic acid hydrazide; 2,2-dimethylpropanohydrazide -Drug Synthesis Database

【结构式】

【分子编号】47803

【品名】Pivalic acid hydrazide; 2,2-dimethylpropanohydrazide

【CA登记号】

【分子式】C₅H₁₂N₂O

【分子量】116.16316

【元素组成】C 51.7% H 10.41% N 24.12% O 13.77%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of methyl pivalate (I) with hydrazine gives the expected hydrazide (II), which is cyclized with methyl or ethyl orthoformate and Ts-OH, yielding the 2-tert-butyl-1,3,4-oxadiazole (III). The condensation of (III) with N-(tert-butoxycarbonyl)-L-valinal (IV) by means of BuLi and MgBr2 in THF affords the alcohol (V), which is treated with HCl in dioxane to provide the amino alcohol (VI). The condensation of (VI) with 2-[5-(benzyloxycarbonyl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-yl]acetic acid (VII) by means of EDC, HOBT and NMM in DMF gives the corresponding amide (VIII), which is treated with DMP or (COCl)2 in order to oxidize the secondary OH group to the ketone (IX). Finally, this compound is deprotected by means of AlCl3 and anisole or HBr in HOAc to afford the target compound.

参考文献中间体

合成目标

【1】 Yamamoto, T.; Okuma, M.; Ohmoto, K.; et al.; Development of orally active nonpeptidic inhibitors of human neutrophil elastase. J Med Chem 2001, 44, 8, 1268.
【3】 Spruce, L.W.; Gyorkos, A. (Cortech, Inc.); Serine protease inhibitors. JP 2001192398; JP 2001507679; WO 9824806 .
【2】 Ohmoto, K.; Matsuoka, S.; Sekioka, T.; Imanishi, H.; Hirota, Y.; Kawabata, K.; Nakai, H.; Yamamoto, T.; Horiuchi, T.; Odagaki, Y.; Toda, M.; Design and synthesis of new orally active nonpeptide inhibitors of human neutrophil elastase. J Med Chem 2000, 43, 26, 4927.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47802	Trimethylacetic acid methyl ester; 2,2-Dimethylpropionic acid methyl ester; Methyl Trimethylacetate; pivalic acid methyl ester; methyl pivalate	598-98-1	C₆H₁₂O₂	详情	详情
(II)	47803	Pivalic acid hydrazide; 2,2-dimethylpropanohydrazide		C₅H₁₂N₂O	详情	详情
(III)	47804	2-(tert-butyl)-1,3,4-oxadiazole		C₆H₁₀N₂O	详情	详情
(IV)	47805	tert-butyl (1S)-1-formyl-2-methylpropylcarbamate		C₁₀H₁₉NO₃	详情	详情
(V)	47806	tert-butyl (1S)-1-[[5-(tert-butyl)-1,3,4-oxadiazol-2-yl](hydroxy)methyl]-2-methylpropylcarbamate		C₁₆H₂₉N₃O₄	详情	详情
(VI)	47807	(2S)-2-amino-1-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-3-methyl-1-butanol		C₁₁H₂₁N₃O₂	详情	详情
(VII)	47808	2-[5-[[(benzyloxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-pyrimidinyl]acetic acid		C₂₀H₁₇N₃O₅	详情	详情
(VIII)	47809	benzyl 1-[2-([(1S)-1-[[5-(tert-butyl)-1,3,4-oxadiazol-2-yl](hydroxy)methyl]-2-methylpropyl]amino)-2-oxoethyl]-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinylcarbamate		C₃₁H₃₆N₆O₆	详情	详情
(IX)	47810	benzyl 1-[2-[((1S)-1-[[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl)amino]-2-oxoethyl]-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinylcarbamate		C₃₁H₃₄N₆O₆	详情	详情

合成路线2

该中间体在本合成路线中的序号：(II)

The intermediate oxadiazole (VIII) has been obtained as follows: The reaction of methyl pivalate (I) with refluxing hydrazine hydrate gives the corresponding hydrazide (II), which is cyclized with methyl orthoformate catalyzed by Ts-OH to yield 2-tert-butyl-1,3,4-oxadiazole (III). The condensation of (III) with N2-(tert-butoxycarbonyl)-N1-methoxy-N1-methyl-DL-valinamide (VI) by means of LDA in THF affords the acylated oxadiazole (VII), which is finally deprotected with HCl in ethyl acetate to provide the target intermediate (VIII).

参考文献中间体

合成目标

【1】 Kojima, T.; Hachiya, K.; Ohmoto, K. (Ono Pharmaceutical Co., Ltd.); 1,3,4-Oxadiazole derivs. and process for producing the same. EP 1162199; WO 0055145 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47802	Trimethylacetic acid methyl ester; 2,2-Dimethylpropionic acid methyl ester; Methyl Trimethylacetate; pivalic acid methyl ester; methyl pivalate	598-98-1	C₆H₁₂O₂	详情	详情
(II)	47803	Pivalic acid hydrazide; 2,2-dimethylpropanohydrazide		C₅H₁₂N₂O	详情	详情
(III)	47804	2-(tert-butyl)-1,3,4-oxadiazole		C₆H₁₀N₂O	详情	详情
(IV)	51959	N-(tert-butoxycarbonyl)valine		C₁₀H₁₉NO₄	详情	详情
(V)	13361	(Methoxyamino)methane; N,O-Dimethylhydroxylamine	1117-97-1	C₂H₇NO	详情	详情
(VI)	51958	tert-butyl 1-[[methoxy(methyl)amino]carbonyl]-2-methylpropylcarbamate		C₁₂H₂₄N₂O₄	详情	详情
(VII)	51957	tert-butyl 1-[[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropylcarbamate		C₁₆H₂₇N₃O₄	详情	详情
(VIII)	47823	2-amino-1-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-3-methyl-1-butanone		C₁₁H₁₉N₃O₂	详情	详情

Extended Information