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【结 构 式】 
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【分子编号】47745 【品名】9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid 【CA登记号】 |
【 分 子 式 】C18H17BrO2 【 分 子 量 】345.23578 【元素组成】C 62.62% H 4.96% Br 23.14% O 9.27% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The lithium dianion of 9-fluorenecarboxylic acid (I) was alkylated with 1,4-dibromobutane (II) to afford bromo acid (III). After conversion of (III) to the corresponding acid chloride by treatment with oxalyl chloride, condensation with 2,2,2-trifluoroethylamine furnished the intermediate bromo amide (IV).
| 【1】 Sun, C.-Q.; Robl, J.A.; Sulsky, R.; et al.; A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. J Med Chem 2001, 44, 6, 851. |
| 【3】 Sulsky, R.B.; Poss, M.A.; Slusarchyk, W.A.; Dickson, J.K.; Biller, S.A.; Tino, J.A.; Magnin, D.R.; Lawrence, R.M.; Robl, J.A.; Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method. US 5760246 . |
| 【2】 Biller, S.A.; Dickson, J.K.; Lawrence, R.M.; Magnin, D.R.; Poss, M.A.; Robl, J.A.; Slusarchyk, W.A.; Sulsky, R.B.; Tino, J.A. (Bristol-Myers Squibb Co.); Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method. EP 0904262; JP 2000502355; WO 9726240 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47744 | 9H-fluorene-9-carboxylic acid; 9-Fluorenecarboxylic acid; Diphenyleneacetic acid; Fluorene-9-carboxylic acid | 1989-33-9 | C14H10O2 | 详情 | 详情 |
| (II) | 11883 | 1,4-Dibromobutane; 1,4-Butylene bromide | 110-52-1 | C4H8Br2 | 详情 | 详情 |
| (III) | 47745 | 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid | C18H17BrO2 | 详情 | 详情 | |
| (IV) | 47746 | 9-(4-bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide | C20H19BrF3NO | 详情 | 详情 |
Extended Information