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【结 构 式】

【分子编号】47719

【品名】(4-bromo-1,1-dimethylbutoxy)(triethyl)silane; 4-bromo-1,1-dimethylbutyl triethylsilyl ether

【CA登记号】

【 分 子 式 】C12H27BrOSi

【 分 子 量 】295.33528

【元素组成】C 48.8% H 9.21% Br 27.06% O 5.42% Si 9.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

Asymmetric Robinson annulation of 2-methylcyclopentane-1,3-dione (II) with (phenylsulfanyl)methyl vinyl ketone (I) using R-(+)-phenylalanine as the catalyst afforded the chiral bicyclic dione (III). Oxidation of the sulfide group of (III) by means of m-chloroperbenzoic acid gave sulfone (IV). This was reduced with LiAlH4 to the trans-hydrindane derivative (V), which was further oxidized to ketone (VI) with Jones reagent. The indaneacetic ester (VII) was obtained by Horner-Emmons condensation of ketone (VI) with triethyl phosphonoacetate, followed by catalytic hydrogenation. Treatment of (VII) with bromide (VIII) in the presence of LDA provided an inseparable mixture (IX and X) of alkylated compounds at the alpha position of the ester and sulfone functions, respectively. Ester reduction of this mixture by means of DIBAL afforded the mixture of alcohols (XI) and (XII), which were separated by chromatography. The desired alcohol (XI) was reduced to the methyl derivative (XIII) via conversion to the corresponding mesylate, which was then reduced by treatment with lithium triethyl borohydride.

1 Marczak, S.; et al.; Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety. Bioorg Med Chem Lett 2001, 11, 1, 63.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 47713 1-(phenylsulfanyl)-3-buten-2-one C10H10OS 详情 详情
(II) 24232 2-methyl-1,3-cyclopentanedione 765-69-5 C6H8O2 详情 详情
(III) 47714 (7aR)-7a-methyl-4-(phenylsulfanyl)-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione C16H16O2S 详情 详情
(IV) 47715 (7aR)-7a-methyl-4-(phenylsulfonyl)-2,3,7,7a-tetrahydro-1H-indene-1,5(6H)-dione C16H16O4S 详情 详情
(V) 47716 (3aS,4S,7aR)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-ol C16H22O3S 详情 详情
(VI) 47717 (3aS,4S,7aR)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-one C16H20O3S 详情 详情
(VII) 47718 ethyl 2-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]acetate C20H28O4S 详情 详情
(VIII) 47719 (4-bromo-1,1-dimethylbutoxy)(triethyl)silane; 4-bromo-1,1-dimethylbutyl triethylsilyl ether C12H27BrOSi 详情 详情
(IX) 47720 ethyl (2S)-2-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]-6-methyl-6-[(triethylsilyl)oxy]heptanoate C32H54O5SSi 详情 详情
(X) 47721 ethyl 2-[(1S,3aS,7aS)-7a-methyl-4-[4-methyl-4-[(triethylsilyl)oxy]pentyl]-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]acetate C32H54O5SSi 详情 详情
(XI) 47729 (2S)-2-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]-6-methyl-6-[(triethylsilyl)oxy]-1-heptanol C30H52O4SSi 详情 详情
(XII) 47722 2-[(1S,3aS,7aS)-7a-methyl-4-[4-methyl-4-[(triethylsilyl)oxy]pentyl]-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]-1-ethanol C30H52O4SSi 详情 详情
(XIII) 47723 (1S,3aS,4S,7aS)-1-[(1S)-1,5-dimethyl-5-[(triethylsilyl)oxy]hexyl]-7a-methyloctahydro-1H-inden-4-yl phenyl sulfone; ([(5S)-5-[(1S,3aS,4S,7aS)-7a-methyl-4-(phenylsulfonyl)octahydro-1H-inden-1-yl]-1,1-dimethylhexyl]oxy)(triethyl)silane C30H52O3SSi 详情 详情
Extended Information