合成路线1

INS-365 can also been obtained by the following ways: 4) Dimerization of uridine-5'-monophosphate tributyl-ammonium salt (I) with bis(tributylammonium) pyrophosphate (II) by means of CDI, followed by purification by semipreparative ion­exchange chromatography. 5) Dimerization of uridine-5'-monophosphate tributyl-ammonium salt (I) with pyrophosphoryl chloride (III) in pyridine, followed by chromatographic purification as before. 6) Condensation of uridine (IV) with POCl3 and bis(tributylammonium) pyrophosphate (II) by means of tributylamine in trimethyl phosphate, followed by chromatographic purification as before. 7) Dimerization of uridine-5'-diphosphate tributylammonium salt (V) by means of CDI in DMF, followed by purification over Dowex 50Wx4 Na+. 8) Condensation of uridine-5'-triphosphate tributylammonium salt (VI) with uridine-5'-monophosphate tributyl-ammonium salt (I) by means of DCC in DMF, followed by chromatographic purification as before. 9) Reaction of uridine-5'-monophosphate tributylammonium salt (I) with CDI in DMF, followed by condensation with uridine-5'-triphosphate (VI) and chromatographic purification as before.