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【结 构 式】 
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【分子编号】47687 【品名】1-iodo-2-methoxyethane; 2-iodoethyl methyl ether 【CA登记号】 |
【 分 子 式 】C3H7IO 【 分 子 量 】185.99245 【元素组成】C 19.37% H 3.79% I 68.23% O 8.6% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)An efficient N-alkylation process suitable for the large-scale synthesis of T-440 has been reported: Alkylation of the previously reported pyridone (I) with 2-methoxyethyl iodide (II) by means of LiH in hot DMF gives the N-alkylated pyridone (II) purified by crystallization. Finally, this compound is reduced with NaBH4 and MeOH in refluxing THF.
| 【1】 Sugahara, M.; et al.; An efficient synthesis of the anti-asthmatic agent T-440: A selective N-alkylation of 2-pyridone. Chem Pharm Bull 2000, 48, 4, 589. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17210 | dimethyl 6,7-diethoxy-1-(2-oxo-1,2-dihydro-4-pyridinyl)-2,3-naphthalenedicarboxylate | C23H23NO7 | 详情 | 详情 | |
| (II) | 47687 | 1-iodo-2-methoxyethane; 2-iodoethyl methyl ether | C3H7IO | 详情 | 详情 | |
| (III) | 17212 | dimethyl 6,7-diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydro-4-pyridinyl]-2,3-naphthalenedicarboxylate | C26H29NO8 | 详情 | 详情 |
Extended Information