(E)-3-bromo-N-methyl-N-(1-naphthylmethyl)-2-propen-1-amine; N-[(E)-3-bromo-2-propenyl]-N-methyl-N-(1-naphthylmethyl)amine -Drug Synthesis Database

【结构式】

【分子编号】47514

【品名】(E)-3-bromo-N-methyl-N-(1-naphthylmethyl)-2-propen-1-amine; N-[(E)-3-bromo-2-propenyl]-N-methyl-N-(1-naphthylmethyl)amine

【CA登记号】

【分子式】C₁₅H₁₆BrN

【分子量】290.20278

【元素组成】C 62.08% H 5.56% Br 27.53% N 4.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

A new method for the short preparation of terbinafine has been described: Condensation of (E)-N-(3-bromoallyl)-N-methyl-N-(1-naphthyl)amine (I) with lithium tert-butylethynyl(triisopropoxy)borate (II) by means of Pd(PPh3)4, and CuI in hot DMF.

参考文献中间体

合成目标

【1】 Oh, C.H.; Jung, S.H.; Efficient coupling reactions of lithium alkynyl(triisopropoxy)borates with aryl halides: Application to the antifungal terbinafine synthesis. Tetrahedron Lett 2000, 41, 44, 8513.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47514	(E)-3-bromo-N-methyl-N-(1-naphthylmethyl)-2-propen-1-amine; N-[(E)-3-bromo-2-propenyl]-N-methyl-N-(1-naphthylmethyl)amine		C₁₅H₁₆BrN	详情	详情
(II)	47515			C₁₅H₃₀BLiO₃	详情	详情

Extended Information