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【结 构 式】

【分子编号】47387

【品名】5-hydroxyisophthalic acid

【CA登记号】618-83-7

【 分 子 式 】C8H6O5

【 分 子 量 】182.13264

【元素组成】C 52.76% H 3.32% O 43.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVII)

Synthesis of the aromatic intermediate (XXXIII): The esterification of the 5-hydroxyisophthalic acid (XVII) with SOCl2 and methanol gives the dimethyl ester (XVIII), which is treated with allyl bromide (XIX) and K2CO3 in refluxing acetone to yield the allyl ether (XX). The thermal isomerization of (XX) affords 4-allyl-5-hydroxyisophthalic acid dimethyl ester (XXI), which is treated with Bn-Br and K2CO3 in refluxing acetone to provide the benzyl ether (XXII). The hydrolysis of the ester groups of (XXII) with NaOH in THF gives the isophthalic acid (XXIII), which by reaction with Br2 and NaHCO3 yields the lactone (XXIV). The reduction of the carboxyl group of (XXIV) with isopropyl chloroformate and NaBH4 in THF/water affords the carbinol (XXV), which is protected with Bom-Cl and DIEA, providing compound (XXVI). The debromination of (XXVI) with Zn and NH4Cl in ethanol/water gives the 2-allylbenzoic acid (XXVII), which by a Curtius rearrangement with DPPA and TEA in refluxing tert-butanol yields the aryl carbamate (XXVIII). The reaction of (XXVIII) with OsO4 and NaIO4 in dioxane/water affords the indoline derivative (XXIX), which is treated with NaBH4 in EtOH to afford the 2-phenylethanol derivative (XXX). The reaction of (XXX) with Tbdms-Cl, TEA and DMAP provides the silyl ether (XXXI), which is treated with Tbdms-OTf and pyridine to give the aniline derivative (XXXII). Finally, this amine is reprotected with Alloc-Cl and NaHCO3 to yield the desired intermediate (XXXIII).

1 Katoh, T.; Terashima, S.; Total synthesis of antitumor antibiotic FR900482. Yuki Gosei Kagaku Kyokaishi 1997, 55, 11, 946.
2 Yoshino, T.; et al.; Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments. Tetrahedron 1997, 53, 30, 10239.
3 Yoshino, T.; et al.; Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments. Tetrahedron Lett 1996, 37, 20, 3475.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XVII) 47387 5-hydroxyisophthalic acid 618-83-7 C8H6O5 详情 详情
(XVIII) 31197 dimethyl 5-hydroxyisophthalate 13036-02-7 C10H10O5 详情 详情
(XIX) 11463 3-Bromo-1-propene; 3-Bromopropene;allyl bromide 106-95-6 C3H5Br 详情 详情
(XX) 47388 dimethyl 5-(allyloxy)isophthalate C13H14O5 详情 详情
(XXI) 47389 dimethyl 4-allyl-5-hydroxyisophthalate C13H14O5 详情 详情
(XXII) 47390 dimethyl 4-allyl-5-(benzyloxy)isophthalate C20H20O5 详情 详情
(XXIII) 47391 4-allyl-5-(benzyloxy)isophthalic acid C18H16O5 详情 详情
(XXIV) 47392 5-(benzyloxy)-3-(bromomethyl)-1-oxo-3,4-dihydro-1H-isochromene-7-carboxylic acid C18H15BrO5 详情 详情
(XXV) 47393 5-(benzyloxy)-3-(bromomethyl)-7-(hydroxymethyl)-3,4-dihydro-1H-isochromen-1-one C18H17BrO4 详情 详情
(XXVI) 47394 5-(benzyloxy)-7-[[(benzyloxy)methoxy]methyl]-3-(bromomethyl)-3,4-dihydro-1H-isochromen-1-one C26H25BrO5 详情 详情
(XXVII) 47395 2-allyl-3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]benzoic acid C26H26O5 详情 详情
(XXVIII) 47396 tert-butyl 2-allyl-3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]phenylcarbamate C30H35NO5 详情 详情
(XXIX) 47397 tert-butyl 4-(benzyloxy)-6-[[(benzyloxy)methoxy]methyl]-2-hydroxy-1-indolinecarboxylate C29H33NO6 详情 详情
(XXX) 47398 tert-butyl 3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]-2-(2-hydroxyethyl)phenylcarbamate C29H35NO6 详情 详情
(XXXI) 47399 tert-butyl 3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)phenylcarbamate C35H49NO6Si 详情 详情
(XXXII) 47400 3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)phenylamine; 3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)aniline C30H41NO4Si 详情 详情
(XXXIII) 47401 allyl 3-(benzyloxy)-5-[[(benzyloxy)methoxy]methyl]-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)phenylcarbamate C34H45NO6Si 详情 详情
Extended Information