8-(1-naphthylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one -Drug Synthesis Database

【结构式】

【分子编号】47326

【品名】8-(1-naphthylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

【CA登记号】

【分子式】C₂₄H₂₅N₃O

【分子量】371.48212

【元素组成】C 77.6% H 6.78% N 11.31% O 4.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

Solution synthesis: In this case the target product is obtained by alkylation of 1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one (VII) with 1-(chloromethyl)naphthalene (VIII) by means of K2CO3 and NaI in refluxing 2-butanone, followed by acylation with methyl bromoacetate (X) in DMF by means of NaH.

参考文献中间体

合成目标

【1】 Watson, B.; Thomsen, C.; Hohlweg, R. (Novo Nordisk A/S); Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes. EP 1080091; WO 9959997 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VII)	18116	1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one	1021-25-6	C₁₃H₁₇N₃O	详情	详情
(VIII)	27408	1-(Chloromethyl)naphthalene	86-52-2	C₁₁H₉Cl	详情	详情
(IX)	47326	8-(1-naphthylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one		C₂₄H₂₅N₃O	详情	详情
(X)	12309	methyl 2-bromoacetate; methyl bromoacetate	96-32-2	C₃H₅BrO₂	详情	详情

Extended Information