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【结 构 式】 
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【分子编号】47284 【品名】(5S)-5-(acetamido)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl di(tert-butyl) phosphite 【CA登记号】 |
【 分 子 式 】C28H40NO7P 【 分 子 量 】533.601902 【元素组成】C 63.03% H 7.56% N 2.62% O 20.99% P 5.8% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The title phosphate ester was prepared from N-acetylcolchinol (I). Treatment of (I) with di-tert-butyl diethylphosphoramidite in the presence of tetrazole provided the phosphite ester (II), which was subsequently oxidized to phosphate (III) by means of MCPBA. The tert-butyl phosphate ester of (III) was finally cleaved using trifluoroacetic acid.
| 【1】 Dougherty, G. (Angiogene Pharmaceuticals Ltd.); Use of colchinol derivs. as vascular damaging agents. WO 9902166 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47283 | N-[(5S)-3-hydroxy-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide | C20H23NO5 | 详情 | 详情 | |
| (II) | 47284 | (5S)-5-(acetamido)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl di(tert-butyl) phosphite | C28H40NO7P | 详情 | 详情 | |
| (III) | 47285 | (5S)-5-(acetamido)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl di(tert-butyl) phosphate | C28H40NO8P | 详情 | 详情 |
Extended Information