合成路线1

In a different procedure, dibenzyl malonate (VI) was alkylated with tetradecyl bromide (B) to afford (VII). This was then condensed with N-phthaloyl-L-alanyl chloride (VIII) in the presence of NaH, and the resulting keto diester (IX) was subjected to hydrogenolysis of the benzyl esters and further thermal decarboxylation to furnish ketone (X). Ketone reduction with simultaneous partial reduction of the phthaloyl group yielded (XI) and (XII) as a diastereomeric mixture. After chromatographic separation, the desired isomers were deprotected by reductive cleavage with NaBH4 to provide the corresponding amino alcohol.