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【结 构 式】

【分子编号】47086

【品名】4-oxo-4H-chromene-3-carbaldehyde

【CA登记号】17422-74-1

【 分 子 式 】C10H6O3

【 分 子 量 】174.15584

【元素组成】C 68.97% H 3.47% O 27.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

3-Formylchromen-4-one (II) was prepared by Vilsmeier formylation of 2'-hydroxyacetophenone (I) with POCl3 and DMF. Cyclization of (II) with guanidine carbonate (III) in refluxing EtOH gave rise to the benzopyranopyrimidine (IV). This was finally condensed with piperidine (V) in the presence of TiCl4 to furnish the title compound.

1 Barocelli, E.; Bertoni, S.; Bruno, O.; Ranise, A.; Schenone, S.; Chiavarini, M.; Ballabeni, V.; Synthesis and pharmacological screening of novel non-acidic gastroprotective antipyretic anti-inflammatory agents with anti-platelet properties. 5-Alkyl/cycloalkylamino substituted 2-amino-5H-[1]benzopyrano[4,3-d]pyrimidines. Arzneim-Forsch Drug Res 2000, 50, 2, 140.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29654 2-hydroxyacetophenone; 1-(2-hydroxyphenyl)-1-ethanone 118-93-4 C8H8O2 详情 详情
(II) 47086 4-oxo-4H-chromene-3-carbaldehyde 17422-74-1 C10H6O3 详情 详情
(III) 14790 Guanidine 113-00-8 CH5N3 详情 详情
(IV) 47087 2-amino-5H-chromeno[4,3-d]pyrimidin-5-ol C11H9N3O2 详情 详情
(V) 10158 Piperidine 110-89-4 C5H11N 详情 详情
Extended Information