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【结 构 式】 
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【分子编号】47071 【品名】2-((E)-2-[(6R)-2-[(benzhydryloxy)carbonyl]-5,5,8-trioxo-7-[(Z)-2-pyridinylmethylidene]-5lambda(6)-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]ethenyl)-1-pyridiniumolate 【CA登记号】 |
【 分 子 式 】C33H25N3O6S 【 分 子 量 】591.64412 【元素组成】C 66.99% H 4.26% N 7.1% O 16.23% S 5.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)Oxidation of (IX) with concomitant double-bond isomerization by means of meta-chloroperbenzoic acid furnished sulfone (X). The benzhydryl ester of (X) was then cleaved using trifluoroacetic acid in anisole to produce the corresponding carboxylic acid, which was finally converted to the title sodium salt by treatment with NaHCO3.
| 【1】 Adam, G.; Doppalapudi, V.R.; Nidamarthy, S.D.; Buynak, J.D.; Rao, A.S.; New cephalosporin-derived beta-lactamase inhibitors. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999, Abst F403. |
| 【2】 Nidamarthy, S.D.; Buynak, J.D.; Rao, A.S.; Doppalapudi, V.R.; Adam, G.C. (Research Corporation Technologies, Inc.); beta-Lactamase inhibiting cpds.. WO 0063213 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 47070 | benzhydryl (2R,6R)-8-oxo-3-[(E)-2-(2-pyridinyl)ethenyl]-7-[(Z)-2-pyridinylmethylidene]-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate | C33H25N3O3S | 详情 | 详情 | |
| (X) | 47071 | 2-((E)-2-[(6R)-2-[(benzhydryloxy)carbonyl]-5,5,8-trioxo-7-[(Z)-2-pyridinylmethylidene]-5lambda(6)-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]ethenyl)-1-pyridiniumolate | C33H25N3O6S | 详情 | 详情 |
Extended Information