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【结 构 式】

【分子编号】46875

【品名】tert-butyl 5-methoxy-2-nitrophenyl(methyl)carbamate

【CA登记号】

【 分 子 式 】C13H18N2O5

【 分 子 量 】282.2964

【元素组成】C 55.31% H 6.43% N 9.92% O 28.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The intermediate phenylenediamine (VI) was prepared as follows. Reaction of 5-chloro-2-nitroaniline (I) with sodium methoxide afforded 5-methoxy-2-nitroaniline (II), which was subsequently converted to the N-Boc derivative (III). Methylation of (III) with iodomethane and NaH, followed by acidic treatment of the resulting N-methyl carbamate (IV), produced the N-methyl aniline (V). The nitro group of (V) was then reduced with the combination SnCl2-NaBH4 to furnish the diamine (VI).

1 Fujita, T.; Wada, K.; Oguchi, M.; Yanagisawa, H.; Fujimoto, K.; Fujiwara, T.; Horikoshi, H.; Yoshioka, T. (Sankyo Co., Ltd.); Benzimidazole derivs., their preparation and their therapeutic use. CA 2177858; EP 0745600; JP 1997295970; JP 2000001487; US 5886014 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15709 5-chloro-2-nitrophenylamine; 5-chloro-2-nitroaniline 1635-61-6 C6H5ClN2O2 详情 详情
(II) 42920 5-methoxy-2-nitrophenylamine; 5-methoxy-2-nitroaniline 16133-49-6 C7H8N2O3 详情 详情
(III) 46874 tert-butyl 5-methoxy-2-nitrophenylcarbamate C12H16N2O5 详情 详情
(IV) 46875 tert-butyl 5-methoxy-2-nitrophenyl(methyl)carbamate C13H18N2O5 详情 详情
(V) 46876 5-methoxy-N-methyl-2-nitroaniline; N-(5-methoxy-2-nitrophenyl)-N-methylamine C8H10N2O3 详情 详情
(VI) 46877 N-(2-amino-5-methoxyphenyl)-N-methylamine; 4-methoxy-N(2)-methyl-1,2-benzenediamine C8H12N2O 详情 详情
Extended Information