2,2,2-trifluoro-N-[2-(6-methoxy-5,10-dioxo-5,10-dihydropyrido[3,2-g]quinolin-4-yl)phenyl]acetamide -Drug Synthesis Database

【结构式】

【分子编号】52020

【品名】2,2,2-trifluoro-N-[2-(6-methoxy-5,10-dioxo-5,10-dihydropyrido[3,2-g]quinolin-4-yl)phenyl]acetamide

【CA登记号】

【分子式】C₂₁H₁₂F₃N₃O₄

【分子量】427.3393096

【元素组成】C 59.02% H 2.83% F 13.34% N 9.83% O 14.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The cyclization of dimethylhydrazone (I) with 4-methoxyquinoline-5,8-dione (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III), which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.

参考文献中间体

合成目标

【1】 Bastide, J.; Darro, F.; Bontemps-Subielos, N.; Frydman, A.; Decaestecker, C.; Delfourne, E.; Kiss, R.; Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid. J Med Chem 2001, 44, 20, 3275.
【2】 Kiss, R.; Bontemps-Subielos, N.; Frydman, A.; Darro, F.; Bastide, J.; Deflourne, E. (Laboratoires L. Lafon); Pharmaceutical compsn. based on polyaromatic cpds.. FR 2790954; WO 0055160 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	48817	N-(2-[(E)-3-[(E)-2,2-dimethylhydrazono]-1-propenyl]phenyl)-2,2,2-trifluoroacetamide	C₁₃H₁₄F₃N₃O	详情	详情
(II)	48819	4-methoxy-5,8-quinolinedione	C₁₀H₇NO₃	详情	详情
(III)	52020	2,2,2-trifluoro-N-[2-(6-methoxy-5,10-dioxo-5,10-dihydropyrido[3,2-g]quinolin-4-yl)phenyl]acetamide	C₂₁H₁₂F₃N₃O₄	详情	详情

Extended Information