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【结 构 式】

【分子编号】48587

【品名】2-[[tert-butyl(dimethyl)silyl]oxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; tert-butyl(dimethyl)silyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl ether

【CA登记号】

【 分 子 式 】C13H23NOSSi

【 分 子 量 】269.48326

【元素组成】C 57.94% H 8.6% N 5.2% O 5.94% S 11.9% Si 10.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VIII)

Reaction of 2,3,4,5,6,7-hexahydrothieno[3,2-c]pyridin-2-one p-toluenesulfonate (VII) with TBDMS-Cl and TEA in dichloromethane gives the silylated enol ether (VIII), which is condensed with 1-cyclopropyl-2-chloro-2-(2-fluorophenyl)ethanone (IX) by means of TEA in the same solvent to provide the adduct (X). Finally, this compound is treated with TEA and DMAP and acetylated with Ac2O.

1 Castaner, J.; Mealy, N.E.; Doggrell, S.A.; CS-747 and R-99224. Drugs Fut 2001, 21, 9, 835.
2 Yamamoto, Y.; Yokota, N.; Kohno, M.; Ataka, K.; Miyata, H. (Ube Industries, Ltd.); 2-Silyloxytetrahydrothienopyridine, salt thereof and process for preparing the same. US 5874581; WO 9611203 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VII) 48585 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2(3H)-one 178688-48-7 C7H9NOS 详情 详情
(VIII) 48587 2-[[tert-butyl(dimethyl)silyl]oxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; tert-butyl(dimethyl)silyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl ether C13H23NOSSi 详情 详情
(IX) 48588 2-chloro-1-cyclopropyl-2-(2-fluorophenyl)-1-ethanone 178688-43-2 C11H10ClFO 详情 详情
(X) 48589 2-[2-[[tert-butyl(dimethyl)silyl]oxy]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-1-ethanone C24H32FNO2SSi 详情 详情
Extended Information