【结 构 式】 |
【分子编号】48587 【品名】2-[[tert-butyl(dimethyl)silyl]oxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; tert-butyl(dimethyl)silyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl ether 【CA登记号】 |
【 分 子 式 】C13H23NOSSi 【 分 子 量 】269.48326 【元素组成】C 57.94% H 8.6% N 5.2% O 5.94% S 11.9% Si 10.42% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VIII)Reaction of 2,3,4,5,6,7-hexahydrothieno[3,2-c]pyridin-2-one p-toluenesulfonate (VII) with TBDMS-Cl and TEA in dichloromethane gives the silylated enol ether (VIII), which is condensed with 1-cyclopropyl-2-chloro-2-(2-fluorophenyl)ethanone (IX) by means of TEA in the same solvent to provide the adduct (X). Finally, this compound is treated with TEA and DMAP and acetylated with Ac2O.
【1】 Castaner, J.; Mealy, N.E.; Doggrell, S.A.; CS-747 and R-99224. Drugs Fut 2001, 21, 9, 835. |
【2】 Yamamoto, Y.; Yokota, N.; Kohno, M.; Ataka, K.; Miyata, H. (Ube Industries, Ltd.); 2-Silyloxytetrahydrothienopyridine, salt thereof and process for preparing the same. US 5874581; WO 9611203 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 48585 | 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2(3H)-one | 178688-48-7 | C7H9NOS | 详情 | 详情 |
(VIII) | 48587 | 2-[[tert-butyl(dimethyl)silyl]oxy]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine; tert-butyl(dimethyl)silyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl ether | C13H23NOSSi | 详情 | 详情 | |
(IX) | 48588 | 2-chloro-1-cyclopropyl-2-(2-fluorophenyl)-1-ethanone | 178688-43-2 | C11H10ClFO | 详情 | 详情 |
(X) | 48589 | 2-[2-[[tert-butyl(dimethyl)silyl]oxy]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)-1-ethanone | C24H32FNO2SSi | 详情 | 详情 |
Extended Information