diethyl 2-(1-ethoxyethyl)succinate -Drug Synthesis Database

【结构式】

【分子编号】47863

【品名】diethyl 2-(1-ethoxyethyl)succinate

【CA登记号】

【分子式】C₁₂H₂₂O₅

【分子量】246.30368

【元素组成】C 58.52% H 9% O 32.48%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Treatment of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid (I) with thionyl chloride afforded the corresponding acid chloride (II). The title triester was then obtained by acylation of 2-(hydroxymethyl)-1,4-butanediol (IV) with acid chloride (II) in the presence of DMAP or Et3N. The triol (IV) has been obtained by reduction of ethane-1,1,2-tricarboxylic acid triethyl ester (III) with LiAlH4 under standard conditions.

参考文献中间体

合成目标

【1】 Otero, D.A.; Bebernitz, G.R.; Dain, J.G.; Strohschein, R.J.; Deems, R.O.; Simpson, W.R.; Reduction in glucose levels in STZ diabetic rats by 4-(2,2-dimethyl-1-oxopropyl)benzoic acid: A prodrug approach for targeting the liver. J Med Chem 2001, 44, 4, 512.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	15453	4-(2,2-dimethylpropanoyl)benzoic acid	C₁₂H₁₄O₃	详情	详情
(II)	15454	4-(2,2-dimethylpropanoyl)benzoyl chloride	C₁₂H₁₃ClO₂	详情	详情
(III)	47863	diethyl 2-(1-ethoxyethyl)succinate	C₁₂H₂₂O₅	详情	详情
(IV)	10910	2-(Hydroxymethyl)-1,4-butanediol	C₅H₁₂O₃	详情	详情

Extended Information