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【结 构 式】 
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【分子编号】47830 【品名】trimethylsilyl 8-[(2-hydroxybenzoyl)amino]octanoate 【CA登记号】 |
【 分 子 式 】C18H29NO4Si 【 分 子 量 】351.5181 【元素组成】C 61.5% H 8.32% N 3.98% O 18.21% Si 7.99% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The silylation of 8-aminooctanoic acid (I) with Tms-Cl in dichloromethane gives the disilylated compound (II), which is treated with 2-hydroxybenzoyl chloride (III) and TEA to yield the corresponding silylated amide (IV). Finally, this compound is desilylated with NaOH to afford the target sodium salt.
| 【1】 Baughman, R.A.; Salo-Kostmayer, S.; O'Toole, D.; Rosado-Gray, C.; Tai, M.; Mercogliano, F.; Leone-Bay, A.; Freeman, J.; Studies directed at the use of a parallel synthesis matrix to increase throughput in an in vivo assay. J Med Chem 2000, 43, 19, 3573. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47828 | 8-aminooctanoic acid | 1002-57-9 | C8H17NO2 | 详情 | 详情 |
| (II) | 47829 | trimethylsilyl 8-[(trimethylsilyl)amino]octanoate | C14H33NO2Si2 | 详情 | 详情 | |
| (III) | 32668 | 2-hydroxybenzoyl chloride | C7H5ClO2 | 详情 | 详情 | |
| (IV) | 47830 | trimethylsilyl 8-[(2-hydroxybenzoyl)amino]octanoate | C18H29NO4Si | 详情 | 详情 |
Extended Information