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【结 构 式】 
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【分子编号】46801 【品名】7H-indolo[3,2-j]phenanthridine-7,13(12H)-dione 【CA登记号】 |
【 分 子 式 】C19H10N2O2 【 分 子 量 】298.30068 【元素组成】C 76.5% H 3.38% N 9.39% O 10.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)Methanol derivative (VI) is then condensed with (X) to give pyridazinone derivative (XI) by first mesylation with mesyl chloride (MsCl) and Et3N in dichloromethane followed by condensation with derivative (X) by means of tert-BuOK in DMF in the presence of 18-crown-6. (Alternatively, instead of mesylation, tosylation of (VI) can be performed by treatment with p-toluenesulfonyl chloride in pyridine; in that case, condensation with (X) occurs by means of NaH in DMF).
| 【1】 Kelly, T.R.; et al.; Synthesis of the potent antimalarials calothrixin A and B. Org Lett 2000, 2, 23, 3735. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 46797 | Indole-3-aldehyde; 3-Formylindole; 1H-Indole-3-carbaldehyde; Indole-3-carboxaldehyde | 487-89-8 | C9H7NO | 详情 | 详情 |
| (II) | 46798 | 1-(methoxymethyl)-1H-indole-3-carbaldehyde | C11H11NO2 | 详情 | 详情 | |
| (III) | 45801 | 4-quinolinecarboxylic acid | 486-74-8 | C10H7NO2 | 详情 | 详情 |
| (IV) | 46799 | N,N-diethyl-4-quinolinecarboxamide | C14H16N2O | 详情 | 详情 | |
| (V) | 46800 | 12-(methoxymethyl)-7H-indolo[3,2-j]phenanthridine-7,13(12H)-dione | C21H14N2O3 | 详情 | 详情 | |
| (VI) | 46801 | 7H-indolo[3,2-j]phenanthridine-7,13(12H)-dione | C19H10N2O2 | 详情 | 详情 |
Extended Information