methyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-heptenoate -Drug Synthesis Database

【结构式】

【分子编号】46719

【品名】methyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-heptenoate

【CA登记号】

【分子式】C₂₄H₃₄O₅

【分子量】402.53096

【元素组成】C 71.61% H 8.51% O 19.87%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The esterification of 17-phenyl-18,19,20-trinorprostaglandin F2alpha (I) with methyl iodide and DBU in acetone gives the corresponding methyl ester (II), which is finally treated with ethylamine in methanol at 80-5 C.

参考文献中间体

合成目标

【1】 Rabasseda, X.; Castaner, J.; Sorbera, L.A.; Leeson, P.A.; Bimatoprost. Drugs Fut 2001, 26, 5, 433.
【2】 Woodward, D.F.; Andrews, S.W.; Burk, R.M.; Garst, M.E. (Allergan, Inc.); Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivs. as therapeutic agents. EP 0660716; JP 1996501310; US 5352708; WO 9406433 .
【3】 Andrews, S.W.; Burk, R.M.; Garst, M.E.; Woodward, D.F. (Allergan, Inc.); Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivs. as therapeutic agents. US 5607978 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43188	(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-heptenoic acid	38344-08-0	C₂₃H₃₂O₅	详情	详情
(II)	46719	methyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-heptenoate		C₂₄H₃₄O₅	详情	详情

Extended Information