• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】46639

【品名】8-(1,3-benzodioxol-5-yl)furo[3,4-e][1,3]benzodioxole

【CA登记号】

【 分 子 式 】C16H10O5

【 分 子 量 】282.2524

【元素组成】C 68.09% H 3.57% O 28.34%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(X)

Alternatively, the condensation of 1,3-benzodioxole-5-carbaldehyde ethylene ketal (VIII) with carbaldehyde (V) by means of n-BuLi gives the hydroxy ketal (IX), which is treated with Ac2O, HOAc and maleic anhydride (XI) at 140 C to perform a Diels-Alder cyclization between the nonisolated isobenzofuran (X) (a reactive diene) and the maleic anhydride (the dienophile), giving rise to the cyclic anhydride (XII). Finally, this compound is reduced with NaBH4 to the target compound along with some structural isomer (XIII) that is separated by chromatography.

1 Urasaki, Y.; et al.; Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations. Cancer Res 2000, 60, 23, 6577.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 10127 1,3-Benzodioxole-5-carbaldehyde; Heliotropine 120-57-0 C8H6O3 详情 详情
(VIII) 46637 5-(1,3-dioxolan-2-yl)-1,3-benzodioxole C10H10O4 详情 详情
(IX) 46638 1,3-benzodioxol-5-yl[5-(1,3-dioxolan-2-yl)-1,3-benzodioxol-4-yl]methanol C18H16O7 详情 详情
(X) 46639 8-(1,3-benzodioxol-5-yl)furo[3,4-e][1,3]benzodioxole C16H10O5 详情 详情
(XI) 11182 2,5-Furandione; Maleic anhydride 108-31-6 C4H2O3 详情 详情
(XII) 46640 10-(1,3-benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxole-7,9-dione C20H10O7 详情 详情
(XIII) 46641 10-(1,3-benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-9(7H)-one C20H12O6 详情 详情
Extended Information