1,2-bis(4-fluorophenyl)-1,2-ethanedione -Drug Synthesis Database

【结构式】

【分子编号】46520

【品名】1,2-bis(4-fluorophenyl)-1,2-ethanedione

【CA登记号】

【分子式】C₁₄H₈F₂O₂

【分子量】246.2131264

【元素组成】C 68.3% H 3.28% F 15.43% O 13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

Treatment of 4,4'-difluorobenzyl (VIII) with isopropylamine and K2CO3 in hot DMSO produced 4,4'-bis(isopropylamino)benzyl (IX). This was then condensed with the intermediate aldehyde (VII) in the presence of ammonium acetate in HOAc to produce the target triaryl imidazole.

参考文献中间体

合成目标

【2】 Zhang, C.; Mjalli, A.M.M. (Ontogen Corp.); Imidazole derivs. as MDR modulators. EP 0999835; US 5840721; WO 9902155 .
【1】 Dixon, R.; Zhang, C.; Sarshar, S.; Mjalli, A.M.M.; Rodarte, J.C.; Moran, E.J.; Benbatoul, K.D.; Krane, S.; 2,4,5-Trisubstituted imidazoles: Novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2. Bioorg Med Chem Lett 2000, 10, 23, 2603.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VII)	46519	4-[(E)-3-ethoxy-1-propenyl]benzaldehyde	C₁₂H₁₄O₂	详情	详情
(VIII)	46520	1,2-bis(4-fluorophenyl)-1,2-ethanedione	C₁₄H₈F₂O₂	详情	详情
(IX)	46521	1,2-bis[4-(isopropylamino)phenyl]-1,2-ethanedione	C₂₀H₂₄N₂O₂	详情	详情

Extended Information