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【结 构 式】 
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【分子编号】46513 【品名】methyl 7-isocyanato-2-phenylthieno[2,3-b]pyrazine-6-carboxylate 【CA登记号】 |
【 分 子 式 】C15H9N3O3S 【 分 子 量 】311.32088 【元素组成】C 57.87% H 2.91% N 13.5% O 15.42% S 10.3% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXVI)The amino ester intermediate (XIII) was treated with phosgene and Et3N, and to the resulting isocyanate (XXVI) was added the primary amine (VIII), producing urea (XXVII). Then, cyclization of (XXVII) in refluxing toluene generated the desired compound, which was isolated as the hydrochloride salt.
| 【1】 Meyer, M.D.; Altenbach, R.J.; Basha, F.; Carroll, W.A.; Drizin, I.; Kerwin, J.F.; Wendt, M.D.; Haight, A.R.; Zhang, W. (Abbott Laboratories Inc.); Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic cpds.. EP 0942911; US 5891882; US 6046207; WO 9824791 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VIII) | 46498 | 4-[(3aR,9bR)-9-methoxy-1,3a,4,9b-tetrahydrochromeno[3,4-c]pyrrol-2(3H)-yl]-1-butanamine; 4-[(3aR,9bR)-9-methoxy-1,3a,4,9b-tetrahydrochromeno[3,4-c]pyrrol-2(3H)-yl]butylamine | C16H24N2O2 | 详情 | 详情 | |
| (XIII) | 46503 | methyl 7-amino-2-phenylthieno[2,3-b]pyrazine-6-carboxylate | C14H11N3O2S | 详情 | 详情 | |
| (XXVI) | 46513 | methyl 7-isocyanato-2-phenylthieno[2,3-b]pyrazine-6-carboxylate | C15H9N3O3S | 详情 | 详情 | |
| (XXVII) | 46514 | methyl 7-[[([4-[(3aR,9bR)-9-methoxy-1,3a,4,9b-tetrahydrochromeno[3,4-c]pyrrol-2(3H)-yl]butyl]amino)carbonyl]amino]-2-phenylthieno[2,3-b]pyrazine-6-carboxylate | C31H33N5O5S | 详情 | 详情 |
Extended Information