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【结 构 式】 
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【分子编号】46500 【品名】3-hydroxy-6-phenyl-2-pyrazinecarboxamide 【CA登记号】 |
【 分 子 式 】C11H9N3O2 【 分 子 量 】215.21148 【元素组成】C 61.39% H 4.22% N 19.53% O 14.87% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)The mixture of 5- and 6-phenyl regioisomers of 2-hydroxy-3-carboxamidopyrazine (IX) and (X), prepared by a known method, was treated with POCl3 and Et3N to produce the corresponding chloro nitriles (XI) and (XII). Condensation of this mixture with methyl thioglycolate in the presence of NaOMe, followed by chromatographic separation of isomers furnished the desired thienopyrazine intermediate (XIII).
| 【1】 Meyer, M.D.; Altenbach, R.J.; Basha, F.; Carroll, W.A.; Drizin, I.; Kerwin, J.F.; Wendt, M.D.; Haight, A.R.; Zhang, W. (Abbott Laboratories Inc.); Benzopyranopyrrole and benzopyranopyridine alpha-1 adrenergic cpds.. EP 0942911; US 5891882; US 6046207; WO 9824791 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 46499 | 3-hydroxy-5-phenyl-2-pyrazinecarboxamide | C11H9N3O2 | 详情 | 详情 | |
| (X) | 46500 | 3-hydroxy-6-phenyl-2-pyrazinecarboxamide | C11H9N3O2 | 详情 | 详情 | |
| (XI) | 46501 | 3-chloro-5-phenyl-2-pyrazinecarbonitrile | C11H6ClN3 | 详情 | 详情 | |
| (XII) | 46502 | 3-chloro-6-phenyl-2-pyrazinecarbonitrile | C11H6ClN3 | 详情 | 详情 | |
| (XIII) | 46503 | methyl 7-amino-2-phenylthieno[2,3-b]pyrazine-6-carboxylate | C14H11N3O2S | 详情 | 详情 |
Extended Information