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【结 构 式】 
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【分子编号】46317 【品名】(1S,4R)-4-((1R,3aR,7aR)-4-[(E)-2-[(3R,4R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-4-(3-[[tert-butyl(dimethyl)silyl]oxy]propoxy)-2-methylenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl)-1-(1-[[tert-butyl(dimethyl)silyl]oxy]-1-methylethyl)pentyl tert-butyl(dimethyl)silyl ether; (6S)-6-[(3R)-3-((1R,3aR,7aR)-4-[(E)-2-[(3R,4R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-4-(3-[[tert-butyl(dimethyl)silyl]oxy]propoxy)-2-methylenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl)butyl]-2,2,3,3,5,5,8,8,9,9-decamethyl-4,7-dioxa-3,8-disiladecane 【CA登记号】 |
【 分 子 式 】C60H120O6Si5 【 分 子 量 】1078.0367 【元素组成】C 66.85% H 11.22% O 8.9% Si 13.03% |
合成路线1
该中间体在本合成路线中的序号：(XXVI)Coupling of the A-ring fragment (XXV) and the C/D-ring fragment (XII) to give adduct (XXVI) was carried out in the presence of tris(dibenzylideneacetone) (chloroform)dipalladium and triphenylphosphine. The silyl protecting groups were finally removed by treatment with tetrabutylammonium fluoride.
| 【1】 Hatakeyama, S.; et al.; Synthesis and biological characterization of 1alpha,24,25-trihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (24-hydroxylated ED-71). Steroids 2001, 66, 3-5, 267. |
| 【2】 Watanabe, H.; Hatakeyama, S.; Kawase, A. (Chugai Pharmaceutical Co. Ltd.); 24-Hydroxyvitamin D derivs.. EP 1061070; WO 9943645 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 46306 | (6S)-6-((3R)-3-[(1R,3aR,7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]butyl)-2,2,3,3,5,5,8,8,9,9-decamethyl-4,7-dioxa-3,8-disiladecane; (2S,5R)-5-[(1R,3aR,7aR)-4-[(E)-bromomethylidene]-7a-methyloctahydro-1H-inden-1-yl]-2-[[tert-butyl(dimethyl)silyl]oxy]-1,1-dimethylhexyl tert-butyl(dimethyl)silyl ether | C31H61BrO2Si2 | 详情 | 详情 | |
| (XXV) | 46316 | (5R,6R)-6-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]-3-butynyl)-2,2,3,3,12,12,13,13-octamethyl-5-vinyl-4,7,11-trioxa-3,12-disilatetradecane; tert-butyl(dimethyl)silyl 3-[[(1R,2R)-2-[[tert-butyl(dimethyl)silyl]oxy]-1-((1R)-1-[[tert-butyl(dimethyl)silyl]oxy]-2-propenyl)-4-pentynyl]oxy]propyl ether | C29H60O4Si3 | 详情 | 详情 | |
| (XXVI) | 46317 | (1S,4R)-4-((1R,3aR,7aR)-4-[(E)-2-[(3R,4R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-4-(3-[[tert-butyl(dimethyl)silyl]oxy]propoxy)-2-methylenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl)-1-(1-[[tert-butyl(dimethyl)silyl]oxy]-1-methylethyl)pentyl tert-butyl(dimethyl)silyl ether; (6S)-6-[(3R)-3-((1R,3aR,7aR)-4-[(E)-2-[(3R,4R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-4-(3-[[tert-butyl(dimethyl)silyl]oxy]propoxy)-2-methylenecyclohexylidene]ethylidene]-7a-methyloctahydro-1H-inden-1-yl)butyl]-2,2,3,3,5,5,8,8,9,9-decamethyl-4,7-dioxa-3,8-disiladecane | C60H120O6Si5 | 详情 | 详情 |