1-[(5-bromopentyl)oxy]-4-nitrobenzene; 5-bromopentyl 4-nitrophenyl ether -Drug Synthesis Database

【结构式】

【分子编号】46286

【品名】1-[(5-bromopentyl)oxy]-4-nitrobenzene; 5-bromopentyl 4-nitrophenyl ether

【CA登记号】

【分子式】C₁₁H₁₄BrNO₃

【分子量】288.1411

【元素组成】C 45.85% H 4.9% Br 27.73% N 4.86% O 16.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The reaction of 4-nitrophenol (I) with 1,5-dibromopentane (II) and NaOH in refluxing water gives the aryl ether (III), which is finally condensed with pyrrolidine (IV) in refluxing ethanol.

参考文献中间体

合成目标

【1】 Ganellin, C.; et al.; Synthesis of potent non-imidazole histamine H3-receptor antagonists. Arch Pharm 1998, 331, 12, 395.
【2】 Stark, H.; Ligneau, X.; Garbarg, M.; Schunack, W.G.; Ganellin, C.R.; Lecomte, J.-M.; Arrang, J.-M.; Leurquin, F.; Sigurd, E.; Schwartz, J.-C. (Societe Civile Bioprojet); Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications. EP 0978512 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	11236	4-Nitrophenol; p-Nitrophenol	100-02-7	C₆H₅NO₃	详情	详情
(II)	30560	1,5-dibromopentane	111-24-0	C₅H₁₀Br₂	详情	详情
(III)	46286	1-[(5-bromopentyl)oxy]-4-nitrobenzene; 5-bromopentyl 4-nitrophenyl ether		C₁₁H₁₄BrNO₃	详情	详情
(IV)	11376	Pyrrolidine	123-75-1	C₄H₉N	详情	详情

Extended Information