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【结 构 式】

【分子编号】46010

【品名】2,6-dimethyl-4H-pyran-4-one

【CA登记号】1004-36-0

【 分 子 式 】C7H8O2

【 分 子 量 】124.13932

【元素组成】C 67.73% H 6.5% O 25.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

N-(3-Aminopropyl)morpholine (I) was protected as the N-Boc derivative (II) and then quaternized with iodomethane to produce the ammonium salt (III). Subsequent acid deprotection of (III) gave amine (IV). Treatment of 2,6-dimethyl-4-pyrone (V) with Lawesson’s reagent in toluene yielded the thiono derivative (VI), which was coupled with amine (IV) to afford the pyridine thione (VII).

1 Singh, J.; et al.; A practical synthesis of an anti-methicillin resistant Staphylococcus aureus cephalosporin BMS-247243. Org Process Res Dev 2000, 4, 6, 488.
2 Kim, O.; et al.; Discovery, synthesis and SAR of BMS-247243, a novel cephalosporin active against methicillin-resistant Staphylococcus aureus (MRSA) and susceptible Staphylococcus aureus (MSSA). 40th Intersci Conf Antimicrob Agents Chemother (Sept 17 2000, Toronto) 2000, Abst F-1062.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25440 3-(4-morpholinyl)-1-propanamine 123-00-2 C7H16N2O 详情 详情
(II) 46007 tert-butyl 3-(4-morpholinyl)propylcarbamate C12H24N2O3 详情 详情
(III) 46008 4-[3-[(tert-butoxycarbonyl)amino]propyl]-4-methylmorpholin-4-ium iodide C13H27IN2O3 详情 详情
(IV) 46009 4-(3-aminopropyl)-4-methylmorpholin-4-ium iodide C8H19IN2O 详情 详情
(V) 46010 2,6-dimethyl-4H-pyran-4-one 1004-36-0 C7H8O2 详情 详情
(VI) 46011 2,6-dimethyl-4H-pyran-4-thione C7H8OS 详情 详情
(VII) 46012 4-[3-[2,6-dimethyl-4-thioxo-1(4H)-pyridinyl]propyl]-4-methylmorpholin-4-ium iodide C15H25IN2OS 详情 详情
Extended Information