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【结 构 式】 
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【分子编号】45899 【品名】2-ethoxy-3-[4-(2-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]ethoxy)phenyl]propanamide 【CA登记号】 |
【 分 子 式 】C16H25NO4S 【 分 子 量 】327.44484 【元素组成】C 58.69% H 7.7% N 4.28% O 19.54% S 9.79% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Debenzylation of propanamide (I) by means of H2 over Pd/C in EtOH/HOAc provides alcohol (II), which is then mesylated with methanesulfonyl chloride (MsCl) and Et3N in CH2Cl2 to yield derivative (III). Finally, coupling of (III) with quinazoline derivative (IV) by means of K2CO3 in DMF affords the desired compound.
| 【1】 Ishii, F.; Koya, H.; Honda, H.; Nagao, Y.; Kotake, J.; Konno, F.; Sato, S.; Koda, T.; Ito, Y.; Preparation of benzazine derivatives with hypoglycemic activity. 19th Symp Med Chem (Nov 17 1999, Tokyo) 1999, Abst 1P-05. |
| 【2】 Kotake, J.; Nagao, Y.; Konno, F.; Sato, S.; Honda, H.; Ishii, F. (SSP Co., Ltd.); alpha-Substd. phenylpropionic acid deriv. and medicine containing the same. CA 2247772; EP 0903343; JP 1999158144 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45897 | 3-[4-[2-(benzyloxy)ethoxy]phenyl]-2-ethoxypropanamide | C20H25NO4 | 详情 | 详情 | |
| (II) | 45898 | 2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propanamide | C13H19NO4 | 详情 | 详情 | |
| (III) | 45899 | 2-ethoxy-3-[4-(2-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]ethoxy)phenyl]propanamide | C16H25NO4S | 详情 | 详情 | |
| (IV) | 45900 | 4-methyl-1(2H)-phthalazinone | C9H8N2O | 详情 | 详情 |
Extended Information