7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-ylamine; 7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-amine -Drug Synthesis Database

【结构式】

【分子编号】45613

【品名】7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-ylamine; 7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-amine

【CA登记号】

【分子式】C₈H₉ClN₂S

【分子量】200.69164

【元素组成】C 47.88% H 4.52% Cl 17.67% N 13.96% S 15.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Nitrosation of 7-chloro-3,4-dihydro-2H-1,4-benzothiazine (I) by means of NaNO2 and H2SO4, followed by reduction with LiAlH4, affords amino derivative (II). Finally, Fischer indole cyclization of (II) with 4-chlorobutanal (III) in refluxing aqueous methanol yields the desired product.

参考文献中间体

合成目标

【1】 Slassi, A.; Isaac, M.; O'Brien, A.; et al.; Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: Potential therapeutic applications for epilepsy and obesity. Bioorg Med Chem Lett 2000, 10, 9, 919.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	45612	7-chloro-3,4-dihydro-2H-1,4-benzothiazine	C₈H₈ClNS	详情	详情
(II)	45613	7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-ylamine; 7-chloro-2,3-dihydro-4H-1,4-benzothiazin-4-amine	C₈H₉ClN₂S	详情	详情
(III)	23428	4-Chlorobutanal	C₄H₇ClO	详情	详情

Extended Information