methyl 2-nitriloacetate -Drug Synthesis Database

【结构式】

【分子编号】45300

【品名】methyl 2-nitriloacetate

【CA登记号】

【分子式】C₃H₃NO₂

【分子量】85.06236

【元素组成】C 42.36% H 3.55% N 16.47% O 37.62%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Reaction of tetrabutylammonium [11C]cyanide (I) with methyl chloroformate in a two phase system afforded labeled methyl cyanoformate (II), which was refluxed in ethanolic HCl to yield diethyl [1-11C]oxalate (III).

参考文献中间体

合成目标

【1】 Thorell, J.O.; et al.; Synthesis of a C-11-labelled nitrated 1,4-dihydroquinoxaline-2,3-dione, the NMDA glycine receptor antagonist ACEA 1021 (Licostinel). J Label Compd Radiopharm 1998, 41, 4, 345-353.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	16993	methyl chlorocarbonate;Carbonochloridic acid methyl ester；[(chlorocarbonyl)oxy]methane；methyl chloroformate	79-22-1	C₂H₃ClO₂	详情	详情
(II)	18001	methyl 2-nitriloacetate; carbonocyanic acid, methyl ester	17640-15-2	C₃H₃NO₂	详情	详情
(II)	45300	methyl 2-nitriloacetate		C₃H₃NO₂	详情	详情
(III)	17571	Diethyl oxalate; Ethyl 2-ethoxy-2-oxoacetate	95-92-1	C₆H₁₀O₄	详情	详情
(III)	45301	ethyl 2-ethoxy-2-oxoacetate		C₆H₁₀O₄	详情	详情

Extended Information