4-[3-(4-fluorophenyl)-2-oxo-2,3-dihydro-1,3-oxazol-4-yl]benzenesulfonyl chloride -Drug Synthesis Database

【结构式】

【分子编号】44955

【品名】4-[3-(4-fluorophenyl)-2-oxo-2,3-dihydro-1,3-oxazol-4-yl]benzenesulfonyl chloride

【CA登记号】

【分子式】C₁₅H₉ClFNO₄S

【分子量】353.7579032

【元素组成】C 50.93% H 2.56% Cl 10.02% F 5.37% N 3.96% O 18.09% S 9.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The synthesis of the title compound has been reported by two related procedures. Cyclization of phenacyl N-(4-fluorophenyl)carbamate (I) in boiling HOAc gave rise to oxazolone (II). Chlorosulfonation of (II), followed by treatment of the resulting sulfonyl chloride (III) with ammonia, yielded the title sulfonamide.

参考文献中间体

合成目标

【1】 Puig Duran, C.; Pujol Noguera, F.; Fernandez Forner, D. (Almirall Prodesfarma, SA); 2-(3H)-Oxazolone derivs. and their use as COX-2 inhibitors. EP 0888316; ES 2125161; JP 2000506876; WO 9734882 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	44953	2-oxo-2-phenylethyl 4-fluorophenylcarbamate	C₁₅H₁₂FNO₃	详情	详情
(II)	44954	3-(4-fluorophenyl)-4-phenyl-1,3-oxazol-2(3H)-one	C₁₅H₁₀FNO₂	详情	详情
(III)	44955	4-[3-(4-fluorophenyl)-2-oxo-2,3-dihydro-1,3-oxazol-4-yl]benzenesulfonyl chloride	C₁₅H₉ClFNO₄S	详情	详情

Extended Information