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【结 构 式】

【分子编号】44950

【品名】(2S)-1-[(2S,5S,8S,11S)-11-[2-(tert-butoxy)-2-oxoethyl]-8-[3-(tert-butoxy)-3-oxopropyl]-2,5-diisopropyl-15,15-dimethyl-4,7,10,13-tetraoxo-14-oxa-3,6,9,12-tetraazahexadec-1-anoyl]-2-pyrrolidinecarboxylic acid

【CA登记号】

【 分 子 式 】C37H63N5O12

【 分 子 量 】769.93372

【元素组成】C 57.72% H 8.25% N 9.1% O 24.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XII)

Racemic allylglycine (I) was protected as the N-Boc derivative (II) and then converted to the Weinreb amide (III) by treatment with N,O-dimethylhydroxylamine and BOP. Reduction of (III) with LiAlH4 afforded aldehyde (IV), which, upon treatment with acetone cyanohydrin (V), furnished the corresponding hydroxy nitrile (VI). Acid hydrolysis of the nitrile (VI) with concomitant Boc group deprotection provided hydroxy acid (VII), which was further reprotected as the N-Boc derivative (VIII). Coupling of hydroxy acid (VIII) with allylamine (IX) yielded amide (X). After Boc group cleavage with HCl in dioxan, the resulting amine (XI) was coupled with pentapeptide (XII) (obtained using a peptide synthesizer under standard conditions), to give the alpha-hydroxyamide (XIII).

1 Hu, Z.; Han, W.; Jiang, X.; Decicco, C.P.; alpha-Ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors. Bioorg Med Chem Lett 2000, 10, 8, 711.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 44941 2-amino-4-pentenoic acid 7685-44-1 C5H9NO2 详情 详情
(II) 44942 2-[(tert-butoxycarbonyl)amino]-4-pentenoic acid C10H17NO4 详情 详情
(III) 44943 tert-butyl 1-[[methoxy(methyl)amino]carbonyl]-3-butenylcarbamate C12H22N2O4 详情 详情
(IV) 44944 tert-butyl 1-formyl-3-butenylcarbamate C10H17NO3 详情 详情
(V) 18029 Acetone cyanohydrin; 2-Hydroxy-2-methylpropanenitrile; 2-Hydroxy-2-methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; alpha-Hydroxyisobutyronitrile 75-86-5 C4H7NO 详情 详情
(VI) 44945 tert-butyl 1-[cyano(hydroxy)methyl]-3-butenylcarbamate C11H18N2O3 详情 详情
(VII) 44946 3-amino-2-hydroxy-5-hexenoic acid C6H11NO3 详情 详情
(VIII) 44947 3-[(tert-butoxycarbonyl)amino]-2-hydroxy-5-hexenoic acid C11H19NO5 详情 详情
(IX) 13672 Allylamine; 2-Propen-1-amine 107-11-9 C3H7N 详情 详情
(X) 44948 tert-butyl 1-[2-(allylamino)-1-hydroxy-2-oxoethyl]-3-butenylcarbamate C14H24N2O4 详情 详情
(XI) 44949 N-allyl-3-amino-2-hydroxy-5-hexenamide C9H16N2O2 详情 详情
(XII) 44950 (2S)-1-[(2S,5S,8S,11S)-11-[2-(tert-butoxy)-2-oxoethyl]-8-[3-(tert-butoxy)-3-oxopropyl]-2,5-diisopropyl-15,15-dimethyl-4,7,10,13-tetraoxo-14-oxa-3,6,9,12-tetraazahexadec-1-anoyl]-2-pyrrolidinecarboxylic acid C37H63N5O12 详情 详情
(XIII) 44951 tert-butyl (4S)-5-[[(1S)-1-([[(1S)-1-([(2S)-2-[([1-[2-(allylamino)-1-hydroxy-2-oxoethyl]-3-butenyl]amino)carbonyl]pyrrolidinyl]carbonyl)-2-methylpropyl]amino]carbonyl)-2-methylpropyl]amino]-4-([(2S)-4-(tert-butoxy)-2-[(tert-butoxycarbonyl)amino]-4-o C46H77N7O13 详情 详情
Extended Information