benzyl (1S)-1-{[((1S)-4-[(aminocarbonyl)amino]-1-{[4-(hydroxymethyl)anilino]carbonyl}butyl)amino]carbonyl}-2-methylpropylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】53571

【品名】benzyl (1S)-1-{[((1S)-4-[(aminocarbonyl)amino]-1-{[4-(hydroxymethyl)anilino]carbonyl}butyl)amino]carbonyl}-2-methylpropylcarbamate

【CA登记号】n/a

【分子式】C₂₆H₃₅N₅O₆

【分子量】513.594

【元素组成】C 60.8% H 6.87% N 13.64% O 18.69%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The title prodrug has been obtained by condensation of the peptide (I) with etoposide (II) by means of PPh3 and DIAD in DMF.

【1】 Toki, B.E.; et al.; Protease-mediated fragmentation of p-amidobenzyl ethers: A new strategy for the activation of anticancer prodrugs. J Org Chem 2002, 67, 6, 1866.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	53571	benzyl (1S)-1-{[((1S)-4-[(aminocarbonyl)amino]-1-{[4-(hydroxymethyl)anilino]carbonyl}butyl)amino]carbonyl}-2-methylpropylcarbamate	n/a	C₂₆H₃₅N₅O₆	详情	详情
(II)	13041	Etoposide; (5R,5aR,8aR,9S)-9-[[(2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one	33419-42-0	C₂₉H₃₂O₁₃	详情	详情

Extended Information