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【结 构 式】 
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【分子编号】53554 【品名】2-(3-Pyridyl)ethylamine; 3-(2-Aminoethyl)pyridine 【CA登记号】20173-24-4 |
【 分 子 式 】C7H10N2 【 分 子 量 】122.16988 【元素组成】C 68.82% H 8.25% N 22.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)Addition of phenylmagnesium bromide (VII) to cyanuric chloride (VI) provided 2,4-dichloro-6-phenyltriazine (VIII). This was subsequently condensed with aniline (V) to afford the aminotriazine (IX). Finally, displacement of the remaining chlorine of (IX) with 2-(3-pyridyl)ethylamine (X) furnished the target diaminotriazine derivative.
| 【1】 Murali Dhar, T.G.; Pitts, W.J.; Guo, J.; et al.; Rapid synthesis of novel inosine monophosphate dehydrogenase (IMPDH) inhibitors. 223rd ACS Natl Meet (April 7 2002, Orlando) 2002, Abst MEDI 214. |
| 【2】 Liu, C.; Leftheris, K.; Pitts, W.J.; Iwanowicz, E.J.; Dhar, T.G.M.; Gu, H.H. (Bristol-Myers Squibb Co.); Cpds. derived from an amine nucleus that are inhibitors of IMPDH enzyme. EP 1126843; US 6399773; WO 0025780 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 39658 | C10H10N2O2 | 详情 | 详情 | ||
| (VI) | 23813 | 2,4,6-Trichloro-s-triazine; Cyanuric chloride; Trichlorocyanidine; Tricyanogen chloride; 2,4,6-Trichloro-1,3,5-triazine | 108-77-0 | C3Cl3N3 | 详情 | 详情 |
| (VII) | 17616 | bromo(phenyl)magnesium; Phenyl Magnesium Bromide | 100-58-3 | C6H5BrMg | 详情 | 详情 |
| (VIII) | 53552 | 4,6-Dichloro-2-phenyltriazine | 1700-02-3 | C9H5Cl2N3 | 详情 | 详情 |
| (IX) | 53553 | N-(4-chloro-6-phenyl-1,3,5-triazin-2-yl)-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amine; 4-chloro-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazin-2-amine | n/a | C19H14ClN5O2 | 详情 | 详情 |
| (X) | 53554 | 2-(3-Pyridyl)ethylamine; 3-(2-Aminoethyl)pyridine | 20173-24-4 | C7H10N2 | 详情 | 详情 |
Extended Information