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【结 构 式】 
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【分子编号】44792 【品名】2-(3-pyridazinyl)acetic acid 【CA登记号】 |
【 分 子 式 】C6H6N2O2 【 分 子 量 】138.12592 【元素组成】C 52.17% H 4.38% N 20.28% O 23.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)2-Pyridyl acetic acid (I) is converted into its methyl ester derivative (II) by means of SOCl2 in MeOH and then vigorously hydrogenated over Pt in MeOH to afford 2-(2-piperidyl)acetic acid methyl (III). Finally, piperidine ester derivative (III) is alkylated on nitrogen with 2-phenylethylbromide (IV) in DMF in the presence of K2CO3.
| 【1】 Dunn, T.; Deutsch, H.M.; Schweri, M.M.; Ye, X.; Synthesis and pharmacology of site-specific cocaine abuse treatment agents: The role of the phenyl group in highly modified methylphenidate analogs as dopamine uptake inhibitors. Med Chem Res 1999, 9, 4, 213. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44792 | 2-(3-pyridazinyl)acetic acid | C6H6N2O2 | 详情 | 详情 | |
| (II) | 44793 | methyl 2-(3-pyridazinyl)acetate | C7H8N2O2 | 详情 | 详情 | |
| (III) | 44794 | methyl 2-hexahydro-3-pyridazinylacetate | C7H14N2O2 | 详情 | 详情 | |
| (IV) | 20730 | 1-(2-bromoethyl)benzene；1-Bromo-2-phenylethane;(2-Bromoethyl)benzene;Phenethyl bromide | 103-63-9 | C8H9Br | 详情 | 详情 |
Extended Information