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【结 构 式】 
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【分子编号】44786 【品名】2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetic acid 【CA登记号】 |
【 分 子 式 】C15H15IN2O5S 【 分 子 量 】462.26505 【元素组成】C 38.97% H 3.27% I 27.45% N 6.06% O 17.31% S 6.94% |
合成路线1
该中间体在本合成路线中的序号：(VI)Synthetic pathway for obtaining EN 292685: Treatment of amino acid (I) with CbzOSu affords the protected amino acid (II), which is further protected by means of Boc2O to yield derivative (III). Condensation of amino acid (III) with N,O-dimethyl hydroxylamine by means of BOP and DIEA provides hydroxamic ester (IV), which is then subjected to hydrogenolysis over Pd/C in CHCl3 for selective deprotection, furnishing compound (V). Coupling of (V) to intermediate (VI) affords derivative (VII), which is then coupled to lithium derivative (VIII) to give protected compound (IX). Finally, the Boc group of (IX) is removed by treatment with TFA.
| 【1】 Soll, R.M.; Lu, T.; Tomczuk, B.E.; Spurlino, J.; Pan, W.; Bone, R.; Green, D.W.; Heteroaryl keto thrombin inhibitors: Design and synthesis. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 285. |
| 【2】 Tumczuk, B.E.; Pan, W.; Soll, R.M.; Lu, T. (3-Dimensional Pharmaceuticals, Inc.); Heteroaryl protease inhibitors and diagnostic imaging agents. WO 0104117 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44766 | (2S)-2-amino-4-([[amino(imino)methyl]amino]oxy)butyric acid | C5H12N4O3 | 详情 | 详情 | |
| (II) | 44767 | 5-[4-[(5-methoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methoxy]benzyl]-3-trityl-1,3-thiazolidine-2,4-dione | C38H32N4O4S | 详情 | 详情 | |
| (III) | 44775 | (11S)-11-[[(benzyloxy)carbonyl]amino]-6-imino-2,2-dimethyl-4-oxo-3,8-dioxa-5,7-diazadodecan-12-oic acid | C18H26N4O7 | 详情 | 详情 | |
| (IV) | 44776 | benzyl (1S)-6-imino-1-[[methoxy(methyl)amino]carbonyl]-10,10-dimethyl-8-oxo-4,9-dioxa-5,7-diazaundec-1-ylcarbamate | C20H31N5O7 | 详情 | 详情 | |
| (V) | 44785 | tert-butyl (6S)-6-amino-8-methyl-7-oxo-3,9-dioxa-2,8-diazadec-1-animidoylcarbamate | C12H25N5O5 | 详情 | 详情 | |
| (VI) | 44786 | 2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetic acid | C15H15IN2O5S | 详情 | 详情 | |
| (VII) | 44787 | tert-butyl (6S)-6-([2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetyl]amino)-8-methyl-7-oxo-3,9-dioxa-2,8-diazadec-1-animidoylcarbamate | C27H38IN7O9S | 详情 | 详情 | |
| (VIII) | 23162 | 1,3-thiazol-2-yllithium | C3H2LiNS | 详情 | 详情 | |
| (IX) | 44788 | tert-butyl imino([[(3S)-3-([2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetyl]amino)-4-oxo-4-(1,2lambda(5),3-thiadiazol-2-yl)butyl]oxy]amino)methylcarbamate | C27H35IN8O8S2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VI)Synthesis of intermediate (VI): Treatment of pyridone (X) with diphenyl phosphoryl azide (DPPA) followed by reaction with benzyl alcohol affords the protected derivative (XI), which then reacts with tert-butyl bromoacetate (XII) by means of Cs2CO3 to provide the acetate derivative (XIII). Hydrogenation of (XIII) over Pd/C allows Cbz removal, giving amine (XIV), which is then condensed with iodo derivative (XV) to furnish sulfonamide compound (XVI). Finally, hydrolysis of (XVI) is achieved by treatment with TFA to afford the target intermediate (VI).
| 【1】 Soll, R.M.; Lu, T.; Tomczuk, B.E.; Spurlino, J.; Pan, W.; Bone, R.; Green, D.W.; Heteroaryl keto thrombin inhibitors: Design and synthesis. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 285. |
| 【2】 Tumczuk, B.E.; Pan, W.; Soll, R.M.; Lu, T. (3-Dimensional Pharmaceuticals, Inc.); Heteroaryl protease inhibitors and diagnostic imaging agents. WO 0104117 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 44786 | 2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetic acid | C15H15IN2O5S | 详情 | 详情 | |
| (X) | 44789 | 6-methyl-2-oxo-1,2-dihydro-3-pyridinecarboxylic acid | C7H7NO3 | 详情 | 详情 | |
| (XI) | 26603 | benzyl 6-methyl-2-oxo-1,2-dihydro-3-pyridinylcarbamate | C14H14N2O3 | 详情 | 详情 | |
| (XII) | 17430 | 2-Bromoacetic acid tert-butyl ester; tert-butyl 2-bromoacetate; tert-Butyl bromoacetate | 5292-43-3 | C6H11BrO2 | 详情 | 详情 |
| (XIII) | 26604 | tert-butyl 2-[3-[[(benzyloxy)carbonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetate | C20H24N2O5 | 详情 | 详情 | |
| (XIV) | 26605 | tert-butyl 2-[3-amino-6-methyl-2-oxo-1(2H)-pyridinyl]acetate | C12H18N2O3 | 详情 | 详情 | |
| (XV) | 44791 | (2-iodophenyl)methanesulfonyl chloride | C7H6ClIO2S | 详情 | 详情 | |
| (XVI) | 44790 | tert-butyl 2-[3-[[(2-iodobenzyl)sulfonyl]amino]-6-methyl-2-oxo-1(2H)-pyridinyl]acetate | C19H23IN2O5S | 详情 | 详情 |