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【结 构 式】

【分子编号】44609

【品名】isopentyl 4-(4-hydroxy-7,8-dimethyl-2-oxo-1,2-dihydro-3-quinolinyl)-2,4-dioxobutanoate

【CA登记号】

【 分 子 式 】C20H23NO6

【 分 子 量 】373.40576

【元素组成】C 64.33% H 6.21% N 3.75% O 25.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XI)

2) The condensation of quinolone (III) with 3 methylbutyl oxalate (X) [obtained from 3 methyl butanol (VIII) and oxalic acid (IX)] by means of NaH yields 3-methylbutyl-4-(4 hydroxy-7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)-2,4-dioxobutanoate (XI), which is then cyclized by means of sulfuric acid. ([*]-labeled compound).

1 Esumi, A.; Jin, Y.; Uohama, K.; Study in vivo of MY-5116. Absorption, distribution and elimination in rats. Clin Rep 1985, 20, 2, 391.
2 Castaner, J.; Prous, J.; Repirinast. Drugs Fut 1987, 12, 1, 37.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 23027 3-acetyl-4-hydroxy-7,8-dimethyl-2(1H)-quinolinone C13H13NO3 详情 详情
(VIII) 23032 3-methyl-1-butanol 123-51-3 C5H12O 详情 详情
(IX) 15713 Oxalic acid 144-62-7 C2H2O4 详情 详情
(IX) 44607 2-hydroxy-2-oxoacetic acid C2H2O4 详情 详情
(X) 23034 isopentyl 2-(isopentyloxy)-2-oxoacetate C12H22O4 详情 详情
(X) 44608 isopentyl 2-(isopentyloxy)-2-oxoacetate C12H22O4 详情 详情
(XI) 23035 isopentyl 4-(4-hydroxy-7,8-dimethyl-2-oxo-1,2-dihydro-3-quinolinyl)-2,4-dioxobutanoate C20H23NO6 详情 详情
(XI) 44609 isopentyl 4-(4-hydroxy-7,8-dimethyl-2-oxo-1,2-dihydro-3-quinolinyl)-2,4-dioxobutanoate C20H23NO6 详情 详情
Extended Information