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【结 构 式】 
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【分子编号】44293 【品名】ethyl 2-[3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl]acetate 【CA登记号】 |
【 分 子 式 】C20H15F3N2O2S 【 分 子 量 】404.4125896 【元素组成】C 59.4% H 3.74% F 14.09% N 6.93% O 7.91% S 7.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Alkylation of 3-indolylacetonitrile (VI) with ethyl bromoacetate provided indoleacetate ester (VII). Condensation of the cyano group of (VII) with amino thiophenol (V) in hot EtOH furnished benzothiophene (VI). The ethyl ester group of (VI) was finally hydrolyzed with NaOH to the title carboxylic acid.
| 【2】 Jones, J.H.; Jones, M.L.; Gunn, D.; Van Zandt, M.C. (The Institutes for Pharmaceutical Discovery, Inc.); Substd. indolealkanoic acids. WO 9950268 . |
| 【3】 Jacot, J.; Sredy, J. (The Institutes for Pharmaceutical Discovery, Inc.); Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substd. indolealkanoic acids. WO 0032180 . |
| 【4】 Van Zandt, M.; Sredy, J. (The Institutes for Pharmaceutical Discovery, Inc.); Compsns. containing a substd. indolealkanoic acid and an angiotensin converting enzyme inhibitor. WO 0164205 . |
| 【5】 Boyd, M.; Robinson, D. (The Institutes for Pharmaceutical Discovery, Inc.); Methods for lowering uric acid levels. WO 0151489 . |
| 【1】 Jones, J.H.; Gunn, D.; Jones, M.L.; Van Zandt, M.C.; Lavoie, D.J.; Sawicki, D.; Sredy, J.; Howard, E.; Podjarny, A.D.; Substituted indolealkanoic acids as novel aldose reductase inhibitors. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 307. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 44290 | 2-amino-3,4,6-trifluorobenzenethiol; 2-amino-3,4,6-trifluorophenylhydrosulfide | C6H4F3NS | 详情 | 详情 | |
| (VI) | 44291 | 3-Indolylacetonitrile;3-Cyanomethyl-1H-indole;3-(Cyanomethyl)indole;Indole-3-acetonitrile;3-Indoleacetonitrile;2-(3-indolyl)acetonitrile;2-(1H-indol-3-yl)acetonitrile;2-(1H-Indol-3-yl)acetonitrile; 3-Indolylacetonitrile | 771-51-7 | C10H8N2 | 详情 | 详情 |
| (VII) | 44292 | ethyl 2-[3-(2-nitriloethyl)-1H-indol-1-yl]acetate | C14H14N2O2 | 详情 | 详情 | |
| (VIII) | 44293 | ethyl 2-[3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]-1H-indol-1-yl]acetate | C20H15F3N2O2S | 详情 | 详情 |
Extended Information