4,5,7-trifluoro-2-methyl-1,3-benzothiazole -Drug Synthesis Database

【结构式】

【分子编号】44289

【品名】4,5,7-trifluoro-2-methyl-1,3-benzothiazole

【CA登记号】

【分子式】C₈H₄F₃NS

【分子量】203.1877096

【元素组成】C 47.29% H 1.98% F 28.05% N 6.89% S 15.78%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Acetylation of 2,3,5,6-tetrafluoroaniline (I), followed by treatment of the resulting acetanilide (II) with P2S5, gave thioamide (III). Cyclization of (III) in the presence of NaH produced the benzothiazole (IV), which was subsequently hydrolyzed to amino thiophenol (V) by means of NaOH in ethyleneglycol.

参考文献中间体

合成目标

【2】 Jones, J.H.; Jones, M.L.; Gunn, D.; Van Zandt, M.C. (The Institutes for Pharmaceutical Discovery, Inc.); Substd. indolealkanoic acids. WO 9950268 .
【3】 Jacot, J.; Sredy, J. (The Institutes for Pharmaceutical Discovery, Inc.); Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substd. indolealkanoic acids. WO 0032180 .
【4】 Boyd, M.; Robinson, D. (The Institutes for Pharmaceutical Discovery, Inc.); Methods for lowering uric acid levels. WO 0151489 .
【5】 Van Zandt, M.; Sredy, J. (The Institutes for Pharmaceutical Discovery, Inc.); Compsns. containing a substd. indolealkanoic acid and an angiotensin converting enzyme inhibitor. WO 0164205 .
【1】 Jones, J.H.; Gunn, D.; Jones, M.L.; Van Zandt, M.C.; Lavoie, D.J.; Sawicki, D.; Sredy, J.; Howard, E.; Podjarny, A.D.; Substituted indolealkanoic acids as novel aldose reductase inhibitors. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 307.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	44286	2,3,5,6-tetrafluoroaniline; 2,3,5,6-tetrafluorophenylamine	700-17-4	C₆H₃F₄N	详情	详情
(II)	44287	N-(2,3,5,6-tetrafluorophenyl)acetamide		C₈H₅F₄NO	详情	详情
(III)	44288	N-(2,3,5,6-tetrafluorophenyl)ethanethioamide		C₈H₅F₄NS	详情	详情
(IV)	44289	4,5,7-trifluoro-2-methyl-1,3-benzothiazole		C₈H₄F₃NS	详情	详情
(V)	44290	2-amino-3,4,6-trifluorobenzenethiol; 2-amino-3,4,6-trifluorophenylhydrosulfide		C₆H₄F₃NS	详情	详情

Extended Information