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【结 构 式】

【分子编号】44284

【品名】7-(tert-butyl)-6-chloro-3-(2,5-difluorophenyl)[1,2,4]triazolo[4,3-b]pyridazine

【CA登记号】

【 分 子 式 】C15H13ClF2N4

【 分 子 量 】322.7446864

【元素组成】C 55.82% H 4.06% Cl 10.98% F 11.77% N 17.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Decarboxylative radical alkylation of 3,6-dichloropyridazine (I) using pivalic acid (II) and ammonium persulfate in the presence of silver nitrate catalyst furnished 3,6-dichloro-4-tert-butylpyridiazine (III). This was then condensed with 2,5-difluorobenzoyl hydrazide (IV) to produce the triazolopyridazine derivative (V). The remaining chlorine atom was finally displaced with (2-methyl-2H-1,2,4-triazol-3-yl)methanol (VI) using NaH in DMF to afford the title compound.

1 Madin, A.; Castro Pineiro, J.L.; Carling, W.R.; Street, L.J.; Russell, M.G.; Moore, K.W.; Guiblin, A.R.; Broughton, H.B. (Merck Sharp & Dohme Ltd.); Substd. triazolo-pyridazine derivs. as ligands for GABA receptors. EP 0915875; WO 9804559 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 11292 3,6-Dichloropyridazine 141-30-0 C4H2Cl2N2 详情 详情
(II) 44281 pivalic acid 75-98-9 C5H10O2 详情 详情
(III) 44282 4-(tert-butyl)-3,6-dichloropyridazine C8H10Cl2N2 详情 详情
(IV) 44283 2,5-difluorobenzohydrazide C7H6F2N2O 详情 详情
(V) 44284 7-(tert-butyl)-6-chloro-3-(2,5-difluorophenyl)[1,2,4]triazolo[4,3-b]pyridazine C15H13ClF2N4 详情 详情
(VI) 44285 (1-methyl-1H-1,2,4-triazol-5-yl)methanol C4H7N3O 详情 详情
Extended Information