【结 构 式】 |
【分子编号】44200 【品名】N-((1R,2S,3R,4R,5S)-5-amino-4-[[(3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-3-hydroxycyclohexyl)acetamide 【CA登记号】 |
【 分 子 式 】C21H39N5O8 【 分 子 量 】489.56956 【元素组成】C 51.52% H 8.03% N 14.31% O 26.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)By alkylation of sisomicin (I) with acetaldehyde (II) and sodium cyanoborohydride in water with some sulfuric acid.
【1】 Castaner, J.; Loren, J.G.; Netilmicin. Drugs Fut 1978, 3, 7, 527. |
【2】 Wright, J.J.; Synthesis of 1-N-ethylsisomicin: a broad-spectrum semisynthetic aminoglycoside antibiotic. J Chem Soc Chem Commun 1976, 6, 206-208. |
【3】 Daniels, P.J.L.; Testa, R.; Tattanahalli, L.; Mallams, A.K.; Wright, J.J.; Weinstein, M.J.; Wagman, G.H. (Schering Corp.); Novel pseudotrisaccharides and methods for their production. DE 2437160; FR 2240015; GB 1473733; US 4029882 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 44199 | (2R,3R,4R,5R)-2-[((1S,2R,3R,4S,6R)-4,6-diamino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxycyclohexyl)oxy]-5-methyl-4-(methylamino)tetrahydro-2H-pyran-3,5-diol; Sisomicin | 32385-11-8 | C19H37N5O7 | 详情 | 详情 |
(II) | 11974 | Acetaldehyde | 75-07-0 | C2H4O | 详情 | 详情 |
(III) | 44200 | N-((1R,2S,3R,4R,5S)-5-amino-4-[[(3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-3-hydroxycyclohexyl)acetamide | C21H39N5O8 | 详情 | 详情 |
Extended Information