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【结 构 式】 
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【分子编号】44142 【品名】N-benzyl-N-(5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methanesulfonamide 【CA登记号】 |
【 分 子 式 】C18H19NO3S 【 分 子 量 】329.4198 【元素组成】C 65.63% H 5.81% N 4.25% O 14.57% S 9.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Reaction of methanesulfonamide derivative (I) with 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (I) and EtMgBr in CH2Cl2 followed by heating with diluted HCl affords compound (III), which is debenzylated and reduced by hydrogenation over Pd/C in MeOH.
| 【1】 Altenbach, R.J.; Holladay, M.W.; Carroll, W.A.; Meyer, M.D.; Kerwin, J.F. Jr.; Kolasa, T.; Rohde, J.; Khilevich, A. (Abbott Laboratories Inc.); Imidazoles and related cpds. as alpha1A agonists. WO 0007997 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 44142 | N-benzyl-N-(5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methanesulfonamide | C18H19NO3S | 详情 | 详情 | |
| (II) | 44143 | 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide | C5H8IN3O2S | 详情 | 详情 | |
| (III) | 44144 | N-benzyl-N-[5-(1H-imidazol-4-yl)-7,8-dihydro-1-naphthalenyl]methanesulfonamide | C21H21N3O2S | 详情 | 详情 |
Extended Information