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【结 构 式】

【分子编号】44142

【品名】N-benzyl-N-(5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methanesulfonamide

【CA登记号】

【 分 子 式 】C18H19NO3S

【 分 子 量 】329.4198

【元素组成】C 65.63% H 5.81% N 4.25% O 14.57% S 9.73%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Reaction of methanesulfonamide derivative (I) with 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (I) and EtMgBr in CH2Cl2 followed by heating with diluted HCl affords compound (III), which is debenzylated and reduced by hydrogenation over Pd/C in MeOH.

1 Altenbach, R.J.; Holladay, M.W.; Carroll, W.A.; Meyer, M.D.; Kerwin, J.F. Jr.; Kolasa, T.; Rohde, J.; Khilevich, A. (Abbott Laboratories Inc.); Imidazoles and related cpds. as alpha1A agonists. WO 0007997 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 44142 N-benzyl-N-(5-oxo-5,6,7,8-tetrahydro-1-naphthalenyl)methanesulfonamide C18H19NO3S 详情 详情
(II) 44143 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide C5H8IN3O2S 详情 详情
(III) 44144 N-benzyl-N-[5-(1H-imidazol-4-yl)-7,8-dihydro-1-naphthalenyl]methanesulfonamide C21H21N3O2S 详情 详情
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