ethyl 1-isopropyl-4-piperidinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】44139

【品名】ethyl 1-isopropyl-4-piperidinecarboxylate

【CA登记号】

【分子式】C₁₁H₂₁NO₂

【分子量】199.29328

【元素组成】C 66.29% H 10.62% N 7.03% O 16.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

An alternative preparation for the title compound consisted in the reductive alkylation of ethyl isonipecotate (IX) with acetone to afford the N-isopropyl isonipecotate (X). After basic hydrolysis of the ethyl ester group of (X), the resulting carboxylic acid (XI) was activated as the mixed anhydride (XII) with isobutyl chloroformate. Anhydride (XII) was finally coupled to aniline (IV) to generate the required amide.

参考文献中间体

合成目标

【1】 Aromatic amides. WO 0039118 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	17410	Ethyl isonipecotate; ethyl 4-piperidinecarboxylate	1126-09-6	C₈H₁₅NO₂	详情	详情
(X)	44139	ethyl 1-isopropyl-4-piperidinecarboxylate		C₁₁H₂₁NO₂	详情	详情
(XI)	44140	1-isopropyl-4-piperidinecarboxylic acid		C₉H₁₇NO₂	详情	详情
(XII)	44141			C₁₄H₂₅NO₄	详情	详情
(XIII)	44135	2-amino-5-chloro-N-(5-chloro-2-pyridinyl)benzamide		C₁₂H₉Cl₂N₃O	详情	详情

Extended Information