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【结 构 式】

【分子编号】44136

【品名】tert-butyl 4-(chlorocarbonyl)-1-piperidinecarboxylate

【CA登记号】

【 分 子 式 】C11H18ClNO3

【 分 子 量 】247.72156

【元素组成】C 53.33% H 7.32% Cl 14.31% N 5.65% O 19.38%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

The condensation between 5-chloro-2-nitrobenzoyl chloride (I) and 2-amino-5-chloropyridine (II) produced the corresponding amide (III). Subsequent catalytic hydrogenation of the nitro group of (III) gave aniline (IV). Acid chloride (VI), prepared from N-Boc-isonipecotic acid (V) and oxalyl chloride, was then coupled to aniline (IV) to furnish amide (VII). Further trifluoroacetic acid-promoted cleavage of the Boc protecting group of (VII) yielded piperidine (VIII). Finally, reductive alkylation with acetone in the presence of sodium triacetoxyborohydride gave rise to the target N-isopropyl piperidine.

1 Kyle, J.A.; et al.; SAR investigations of N-aryl-2-[(piperidin-4-ylcarbonyl)amino]benzamide factor Xa inhibitors. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 288.
2 Aromatic amides. WO 0039118 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 44133 5-chloro-2-nitrobenzoyl chloride C7H3Cl2NO3 详情 详情
(II) 18559 5-Chloro-2-pyridinylamine; 5-Chloro-2-pyridinamine; 2-Amino-5-chloropyridine 1072-98-6 C5H5ClN2 详情 详情
(III) 44134 5-chloro-N-(5-chloro-2-pyridinyl)-2-nitrobenzamide C12H7Cl2N3O3 详情 详情
(IV) 44135 2-amino-5-chloro-N-(5-chloro-2-pyridinyl)benzamide C12H9Cl2N3O 详情 详情
(V) 17404 1-(tert-butoxycarbonyl)-4-piperidinecarboxylic acid; 1-BOC-piperidine-4-carboxylic acid; N-Boc-isonipecotic acid 84358-13-4 C11H19NO4 详情 详情
(VI) 44136 tert-butyl 4-(chlorocarbonyl)-1-piperidinecarboxylate C11H18ClNO3 详情 详情
(VII) 44137 tert-butyl 4-[(4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]anilino)carbonyl]-1-piperidinecarboxylate C23H26Cl2N4O4 详情 详情
(VIII) 44138 N-(4-chloro-2-[[(5-chloro-2-pyridinyl)amino]carbonyl]phenyl)-4-piperidinecarboxamide C18H18Cl2N4O2 详情 详情
Extended Information