• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】44056

【品名】(1R)-6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 4-[(1R)-6-chloro-7,8-dimethoxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]phenyl methyl ether

【CA登记号】

【 分 子 式 】C20H24ClNO3

【 分 子 量 】361.8682

【元素组成】C 66.38% H 6.68% Cl 9.8% N 3.87% O 13.26%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The optical resolution of the racemic 6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (I) (+)- or (-)-dibenzoyltartaric acid gives the corresponding (R)-isomer (II), which is N-demethylated by means of BrCN to yield 6-chloro-7,8-dimethoxy-1(R)-(4-methoxyphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (III). Finally, this compound is fully demethylated by treatment with BBr3. The optical resolution can also be performed by treatment of racemic (III) with (+)- or (-)-dibenzoyltartaric acid.

1 Hieble, J.P.; Wilson III, J.W.; Weinstock, J.; The chemistry and pharmacology of 3-benzazepines derivatives. Drugs Fut 1985, 10, 8, 645.
2 Webb, R.L.; Horodniak, J.W.; Dandridge, P.A.; Sarau, H.M.; Setler, P.E.; Weinstock, J.; Ackerman, D.M.; Kaiser, C.; Matz, E.D.; Stereoselectivity of some new dopamine receptor agonists. Acta Pharm Suec 1983, 2, 132-150.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 44055 4-(6-chloro-7,8-dimethoxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl)phenyl methyl ether; 6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine C20H24ClNO3 详情 详情
(II) 44056 (1R)-6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine; 4-[(1R)-6-chloro-7,8-dimethoxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]phenyl methyl ether C20H24ClNO3 详情 详情
(III) 44057 (1R)-6-chloro-7,8-dimethoxy-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine; 4-[(1R)-6-chloro-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]phenyl methyl ether C19H22ClNO3 详情 详情
Extended Information