【结 构 式】 |
【分子编号】44046 【品名】2-chloro-N-(3-chlorophenethyl)-N-methyl-1-ethanamine; N-(2-chloroethyl)-N-(3-chlorophenethyl)-N-methylamine 【CA登记号】 |
【 分 子 式 】C11H15Cl2N 【 分 子 量 】232.15224 【元素组成】C 56.91% H 6.51% Cl 30.54% N 6.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(V)The condensation of labeled 2-(3-chlorphenyl)acetic acid (I) with N-methylethanolamine (II) by means of SOCl2 gives the corresponding amide (III), which is reduced with BH3, yielding the tertiary amine (IV). The reaction of (IV) with PCl3 affords the chloroethylamine (V), which is finally cyclized by means of AlCl3 to provide the target benzazepine.
【1】 Hieble, J.P.; Wilson III, J.W.; Weinstock, J.; The chemistry and pharmacology of 3-benzazepines derivatives. Drugs Fut 1985, 10, 8, 645. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 39705 | 2-(3-chlorophenyl)acetic acid; 3-chlorophenylacetic acid | 1878-65-5 | C8H7ClO2 | 详情 | 详情 |
(I) | 44628 | 2-(3-chlorophenyl)acetic acid | C8H7ClO2 | 详情 | 详情 | |
(II) | 13324 | 2-Methylaminoethanol; 2-(Methylamino)-1-ethanol | 109-83-1 | C3H9NO | 详情 | 详情 |
(III) | 44044 | 2-(3-chlorophenyl)-N-(2-hydroxyethyl)-N-methylacetamide | C11H14ClNO2 | 详情 | 详情 | |
(III) | 44629 | 2-(3-chlorophenyl)-N-(2-hydroxyethyl)-N-methylacetamide | C11H14ClNO2 | 详情 | 详情 | |
(IV) | 44045 | 2-[(3-chlorophenethyl)(methyl)amino]-1-ethanol | C11H16ClNO | 详情 | 详情 | |
(IV) | 44630 | 2-[(3-chlorophenethyl)(methyl)amino]-1-ethanol | C11H16ClNO | 详情 | 详情 | |
(V) | 44046 | 2-chloro-N-(3-chlorophenethyl)-N-methyl-1-ethanamine; N-(2-chloroethyl)-N-(3-chlorophenethyl)-N-methylamine | C11H15Cl2N | 详情 | 详情 | |
(V) | 44631 | 2-chloro-N-(3-chlorophenethyl)-N-methyl-1-ethanamine; N-(2-chloroethyl)-N-(3-chlorophenethyl)-N-methylamine | C11H15Cl2N | 详情 | 详情 |
Extended Information