|
【结 构 式】 
|
【分子编号】43899 【品名】4-(2-quinolinylmethoxy)phenyl 2-[(2-trityl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl ether; 2-[[4-([2-[(2-trityl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl]oxy)phenoxy]methyl]quinoline 【CA登记号】 |
【 分 子 式 】C44H35N5O2 【 分 子 量 】665.7944 【元素组成】C 79.38% H 5.3% N 10.52% O 4.81% |
合成路线1
该中间体在本合成路线中的序号：(XIII)Synthesis of the target compound 147690: This compound has been obtained by two similar ways: 1. The condensation of intermediate 4-(2-quinolinylmethoxy)phenol (V) with intermediate 5-[2-(bromomethyl)benzyl]-2-(triphenylmethyl)-2H-tetrazole (X) by means of KF/alumina in acetonitrile gives the adduct (XIII), which is finally deprotected to the target compound by means of HCl in methanol/THF. 2. The condensation of intermediate 4-(2-quinolinylmethoxy)phenol (V) with intermediate 5-[2-(bromomethyl)benzyl]-2-(tetrahydropyran-2-yl)-2H-tetrazole (XII) by means of KF/alumina in acetonitrile gives the adduct (XIV), which is finally deprotected to the target compound by means of HCl in methanol/THF.
| 【1】 Sledeski, A.W.; et al.; A convergent synthesis of an LTD4 antagonist, RG12525. Tetrahedron Lett 1997, 38, 7, 1129. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 13164 | 4-(2-Quinolinylmethoxy)phenol | C16H13NO2 | 详情 | 详情 | |
| (X) | 43896 | 5-[2-(bromomethyl)benzyl]-2-trityl-2H-1,2,3,4-tetraazole | C28H23BrN4 | 详情 | 详情 | |
| (XII) | 43898 | 5-[2-(bromomethyl)benzyl]-2-tetrahydro-2H-pyran-2-yl-2H-1,2,3,4-tetraazole | C14H17BrN4O | 详情 | 详情 | |
| (XIII) | 43899 | 4-(2-quinolinylmethoxy)phenyl 2-[(2-trityl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl ether; 2-[[4-([2-[(2-trityl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl]oxy)phenoxy]methyl]quinoline | C44H35N5O2 | 详情 | 详情 | |
| (XIV) | 43900 | 2-[[4-([2-[(2-tetrahydro-2H-pyran-2-yl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl]oxy)phenoxy]methyl]quinoline; 4-(2-quinolinylmethoxy)phenyl 2-[(2-tetrahydro-2H-pyran-2-yl-2H-1,2,3,4-tetraazol-5-yl)methyl]benzyl ether | C30H29N5O3 | 详情 | 详情 |