2-quinolinylmethyl 4-methylbenzenesulfonate -Drug Synthesis Database

【结构式】

【分子编号】43891

【品名】2-quinolinylmethyl 4-methylbenzenesulfonate

【CA登记号】

【分子式】C₁₇H₁₅NO₃S

【分子量】313.37704

【元素组成】C 65.16% H 4.82% N 4.47% O 15.32% S 10.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Synthesis of intermediate 4-(2-quinolinylmethoxy)phenol (V): The oxidation of 2-methylquinoline with urea and H2O2 in dichloromethane gives the N-oxide (II), which is treated with TsCl and K2CO3 in acetonitrile to yield the tosylate (III). Finally this compound is condensed with an excess of hydroquinone by means of NaOH in methanol/acetonitrile to afford the target intermediate (V).

参考文献中间体

合成目标

【1】 Sledeski, A.W.; et al.; A convergent synthesis of an LTD4 antagonist, RG12525. Tetrahedron Lett 1997, 38, 7, 1129.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13161	Quinaldine; 2-Methylquinoline	91-63-4	C₁₀H₉N	详情	详情
(II)	43890	2-methyl-1-quinoliniumolate		C₁₀H₉NO	详情	详情
(III)	43891	2-quinolinylmethyl 4-methylbenzenesulfonate		C₁₇H₁₅NO₃S	详情	详情
(IV)	13163	p-Dihydrobenzene; Hydroquinone	123-31-9	C₆H₆O₂	详情	详情
(V)	13164	4-(2-Quinolinylmethoxy)phenol		C₁₆H₁₃NO₂	详情	详情

Extended Information