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【结 构 式】 
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【分子编号】43815 【品名】(2,4-difluorophenyl)(iodo)zinc 【CA登记号】 |
【 分 子 式 】C6H3F2IZn 【 分 子 量 】305.3810964 【元素组成】C 23.6% H 0.99% F 12.44% I 41.56% Zn 21.41% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)A facile preparation method for diflunisal has been reported: Reaction of 2,4-difluoroiodobenzene (I) with powdered Zn activated with 1,2-dibromoethane in DMF gives the 2,4-difluorophenylzinc iodide (II), which is condensed with 2-acetoxy-5-iodobenzoic acid methyl ester (III) by means of Pd(PPh3)4 in DMF to yield 4-acetoxy-2',4'-difluorobiphenyl-3-carboxylic acid methyl ester (IV). Finally, this compound is deacetylated and hydrolyzed with NaHCO3 in THF/water.
| 【1】 Lee, S.J.; Chung, S.; Jeong, N.; Choi, K.H.; A facile preparation of fluoroaryl zinc halides: An application to the synthesis of diflunisal. Bull Korean Chem Soc 2000, 21, 2, 165. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43814 | 2,4-difluoro-1-iodobenzene | 2265-93-2 | C6H3F2I | 详情 | 详情 |
| (II) | 43815 | (2,4-difluorophenyl)(iodo)zinc | C6H3F2IZn | 详情 | 详情 | |
| (III) | 43816 | methyl 2-(acetoxy)-5-iodobenzoate | C10H9IO4 | 详情 | 详情 | |
| (IV) | 43817 | methyl 4-(acetoxy)-2',4'-difluoro[1,1'-biphenyl]-3-carboxylate | C16H12F2O4 | 详情 | 详情 |
Extended Information