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【结 构 式】 
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【分子编号】43813 【品名】(Z)-4-hydroxy-4-(6-methoxy-2-naphthyl)-3-buten-2-one 【CA登记号】73356-31-7 |
【 分 子 式 】C15H14O3 【 分 子 量 】242.27436 【元素组成】C 74.36% H 5.82% O 19.81% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)A short, simple and economical process for large-scale preparation of nabumetone has been reported: Condensation of commercially available 2-acetyl-6-methoxynaphthalene (2-acetylnaroline) (I) with ethyl acetate (II) by means of potassium sec-butoxide (sec-BuOK) in DMSO gives the ketoenol (III), which is reduced with H2 over Pd/C in ethyl acetate with a catalytic amount of sulfuric acid.
| 【1】 Nageshwar, D.; Devi, A.S.; Reddy, G.O.; Sarma, M.R.; Reddy, G.B.; Vyas, K.; Prabhakar, C.; Reddy, C.M.; Babu, J.M.; Process research and structural studies on nabumetone. Org Process Res Dev 1999, 3, 2, 121. |
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