7-ethyloctahydro-2H-pyrido[1,2-a]pyrazine -Drug Synthesis Database

【结构式】

【分子编号】43690

【品名】7-ethyloctahydro-2H-pyrido[1,2-a]pyrazine

【CA登记号】

【分子式】C₁₀H₂₀N₂

【分子量】168.28228

【元素组成】C 71.37% H 11.98% N 16.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The cyclization of 5-ethylpiperidine-2-carboxylic acid ethyl ester (I) with aziridine (II) in ethanol gives 7-ethylperhydropyrido[1,2-a]pyrazin-1-one (III), which is reduced with LiAlH4 to yield 7-ethylperhydropyrido[1,2-a]pyrazine (IV). The reaction of (IV) with NaNO2/HCl, followed by reduction with LiAlH4, affords 7-ethylperhydropyrido[1,2-a]pyrazin-2-amine (V), which is finally condensed with rifamicin SV-3-carbaldehyde (VI).

参考文献中间体

合成目标

【1】 Hauffe, S.; Tosch, W.; Batt, E.; Ashtekar, D.R.; Costa-Pereira, R.; Vischer, W.; Traxler, P.; Degen, P.; Zak, O.; Imhof, P.; Gowrishankar, R.; 3-Formylrifamycin SV-hydrazones with diazabicycloalkyl side-chains: New rifamycins aganist tuberculosis with long plasma half-lives. 27th Intersci Conf Antimicrob Agents Chemother 1987, Abst 278.
【2】 Traxler, P. (Novartis Corp.); Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compsns. for treating tuberculosis. US 4681938 .
【3】 Traxler, P.; Vischer, W.; Zak, O.; New Rifamycins. Drugs Fut 1988, 13, 9, 845.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	43688	ethyl 5-ethyl-2-piperidinecarboxylate		C₁₀H₁₉NO₂	详情	详情
(II)	10151	Ethyleneimine; Aziridine; Azirane	151-56-4	C₂H₅N	详情	详情
(III)	43689	7-ethylhexahydro-2H-pyrido[1,2-a]pyrazin-1(6H)-one		C₁₀H₁₈N₂O	详情	详情
(IV)	43690	7-ethyloctahydro-2H-pyrido[1,2-a]pyrazine		C₁₀H₂₀N₂	详情	详情
(V)	43691	7-ethyloctahydro-2H-pyrido[1,2-a]pyrazin-2-amine; 7-ethyloctahydro-2H-pyrido[1,2-a]pyrazin-2-ylamine		C₁₀H₂₁N₃	详情	详情
(VI)	43692	26-formyl-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),1(29),2,4,9,19,21,25,27-nonaen-13-yl acetate		C₃₈H₄₇NO₁₃	详情	详情

Extended Information